Comparison of Memory Impairment Due to Electroconvulsive Therapy in Depressed Patients Receiving Liothyronine and Vitamin B12

The purpose of this study was to evaluate the effect of liothyronine on reduce-ing memory impairment in patients receiving electroconvulsive therapy(ECT). Based on a double blind experimental design, 40 clinically depressed ECT candidate women (age range 20-50) were selected and randomly allocated to experimental and control groups. After carrying out a memory test, the experimental group was allocated to liothyro-nine and the control group was allocated to vitamin B12. After six sessions of bilateral ECT on a three per week basis, both groups underwent the same memory tests and the results were com-pared. The difference in memory in the experimental group was significant, but in the control group was not significant, before and after ECT. In depressed ECT candidate patients, liothyronine prescription can reduce memory impairment.