Outcome of newborns conceived through artificial reproductive techniques in Tehran Iran

Today there is a rise in the number of newborns conceived by artificial reproductivetechniques (ART). Numerous studies have been performed on the perinatal outcome of these pregnancies.However, there is limited data about the condition of health of these newborns in Iran.

Regarding the higher prevalence of probable complications and symptomatic congenitalanomalies, we aimed to determine the state of health of newborns born by ART.

A total of 109 newborn who were conceived through ART and 479 newborns ofspontaneous conception were enrolled into our study.The study was prospective, case-control study in Tehran, Iran, from March 2003 to March 2004. Bothcase and control groups were adjusted in regard to race, sex, type of delivery, chronic disease of mother,age of mother, and antenatal steroids administration. All newborns were examined by neonatologist afterbirth and their outcome were followed until hospital discharge or death.Data pertaining to clinical and laboratory findings of newborns and death were entered into aquestionnaire and subsequently analyzed by appropriate statistical tests. Confidence interval was 95%.

Prematurity, low birth weight (LBW), very low birth weight (VLBW), twins and triplets, smallfor gestational age (SGA), need for resuscitation at birth, respiratory distress syndrome (RDS) and NICUadmission were significantly higher among newborns born after ART than those born throughspontaneous conception (p<0.05). Regression logistic analysis showed that RDS and NICU admissionwere more strongly associated with weight at birth and gestational age than with method of conception.However, increased rate of SGA in the case group was associated with multiple pregnancy. Also, therewas no significant statistical relationship between the method of conception and the prevalence ofcongenital anomalies, large for gestational age (LGA), congenital pneumonia, necrotizing entrocolitis(NEC), respiratory air leakage syndromes (ALS), hydrops fetalis, hyperbilirubinemia sepsis, meconiumaspiration syndrome (MAS), isseminated intravascular coagulopathy (DIC), cardiac failure, lunghemorrhage, hypoglycemia, hypocalcemia, neutropenia, thrombocytopenia and hemolysis.

Newborns who were conceived by ART were more likely in need of resuscitation at birthregardless of other factors. Furthermore, newborns born after ART were at higher risk of developingprematur birth, LBW, and multiple birth.