Quality assessment of glucosamine preparations available in drug market of Iran

the purpose of this study was the evaluation of pharmaceutical properties and quality control of glucosamine preparations available in Iran drug market. 10 commercial products were selected and evaluated for some Pharmaceutical characteristics such as content uniformity, assay, weight variation and dissolution test. Dِetermination of glucosamine was performed according to a new high performance liquid chromatography (HPLC) method developed for the first time. The method was based on pre column derivatization of glucosamine by orthophthaldialdehyde (OPA). the results of these tests about 10 commercial products were as follow: assay was between 13. 69% and 138. 72%, for content uniformity RSD% was between 4. 17 and 26. 60, weight variation had RSD% between 0. 69 and 7. 5. Dissolved glucosamine (%) in dissolution test was between 20. 03% and 98. 71%. Similarity factor test on the results of dissolution test showed that at least 3 commercial products have not been in an acceptable range in comparison with reference product (No. 2). according to these results, good controls on the quality of food supplements are required.