مصاحبه با مدیران اتحادیه و تعاونی های دامداری استان خراسان

Human nonspecific polyclonal IgG was labeled with125I through direct and indirect labeling methods using chloramine-T and a non-Phenolic radioiodinated intermediate N-Succinimidyl-4-[125I] iodobenzoate (125I-SIB), respectively. Tissue distribution of radioiodinated IgG was assessed in normal and induced inflammation mice. Although, radioiodinated IgG accumulated in the inflammatory area, results showed decreased thyroid and stomach activity and improved inflammatory thigh-to-normal tissue ratios with the indirect labeling method (125I-IB-IgG) compared with direct labeling method (125I-IgG), indicating reduced in vivo deiodination. These results indicate that the 125I-SIB is probably a preferable approach for labeling antibodies with iodine radioisotopes.