Selective disappearance of donor-specific antibodies and absence of acute rejection after liver treansplantation in a patientwith a strongly positive lymphocyte crossmatch

We report on a young female, who received a cadaveric liver transplant from a donor who was a zero antigen match, and to whom she has had a strongly positive crossmatch. Immediately after transplantation, her panel reactive antibodies dropped from 55% to 0%, a value which remained for nearly 3 weeks. She subsequently, redeveloped her pretransplant anti-HLA antibodies, though at a lower level, with the exception of those specific to the donor HLA antigens. She also did not develop any acute rejection episodes during the 6 months of follow-up.