Relationship between Helicobacter pylori infection and cardiac syndrome X

There is no obvious etiology for cardiac syndrome X (CSX). Some mechanisms, such as endothelial dysfunction and estrogen deficiency have been involved. In this study, we tried to find the association between Helicobacter pylori (HP) infection and cardiac syndrome X. In this case control study in year 2007, 54 cardiac syndrome X-affected patients and 168 referred patients to the Taleghani hospital for elective surgery were included. Data were collected by interview physical examination, laboratory and angiographic findings. Then, Serum anti-Helicobacter pylori antibody (IgG) was determined by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using Chi-square, and Mantel- Hanzel tests with SPSS software. According to the results of this study, 54 patients were considered as case group and meeting diagnostic criteria for cardiac syndrome X. The mean age of subjects was 54.54±8.99 years (range=38 to 72 years). From the total 54 case group patients, 44 patients (81.5%) were positive for helicobacter pylori and from 168 control patients, 95 patients (56.5%) were positive (P<0.001). There was no significant difference between history of diabetes and blood pressure in H.pylori-positive cardiac syndrome X-affected patients According to the results of this study, a probable role for HP infection seems to be involved in the pathogenesis of CSX.