The analgesic effects of aqueous part of Carum copticum (L.) C. B. Clarke extract on chronic pain and comparison with oil part of extract in mice

One of the important aims of biological investigations is finding substances which are involved in relieving pain. Application of medicinal herbs for relieving pain is very useful. Carum copticum (L.) C. B. Clarke from Umbelliferae family has been introduced as an analgesic agent in Iranian traditional literature which is widely used for relieving neuropathy pain and headache. This study was conducted to investigate the analgesic effect of Carum copticum fruit on formalin induced pain as compared with oil part of Carum copticum. Formalin test was used as a standard pain inducing test and the analgesic effect of intra peritoneal injection of 20ml/kg of Carum copticum extract were evaluated. Our findings showed that aqueous part of Carum copticum extract had no effect during one hour formalin test as compared with control group (P>0.05). Therefore, due to the analgesic effect of essential fatty acids and its crude extract of Carum copticum, the non analgesia property might be related to absent of oil part.