Predictive factors of survival time after haematopoietic stem cell transplant in acute myeloid leukemia patients who received allogeneic bone marrow transplantation from matched sibling donors using generalized gamma models

This paper used Generalized Gamma (GG) distribution to find the predictive factors of overallsurvival (OS) after haematopoietic stem cell transplant (HSCT) in acute myeloid leukemia patients. Discrimination among the exponential, Weibull, GG, log-logistic, and lognormal distributions was done using maximum likelihood and Akaike information criteria. The 5-year OS in 301 patients was 65% (95%CI: 60.7-69.3). Peak mortality hazard occurred at months6-7 after HSCT then, it was U Shape. The data was fitted by GG distribution better than other distributions.Univariate analysis using GG distribution showed a positive association between OS with dose of infused WBC (P=0.018), CD3 (p=0.001), no relapse (P<0.001), cGVHD (P<0.001), and platelet recovery (P<0.001).Multivariate analysis indicated that, OS has relationship with relapse (P<0.001), platelet recovery (P=0.004),disease status at transplant (P=0.036) and aGVHD (P=0.036). We showed that GG distribution can be a useful tool for recognizing prognostic factors of OS inAML patients.