THE INCIDENCE RATE OF RESISTANCE OF PROPIONIBACTERIUM AND STAPHYLOCOCCUS EPIDERMIS TO ANTIBIOTICS USED IN TREATMENT OF ACNE

The purpose of this study was to compare the resistance of propiobacteriom acne (PA) and staphylococcus epidermis(SE) to antibiotics in patients that have been treated with antibiotics, With those cases without previous history of therapy as the control group. 60 patients were included in this study. At the time of sampling, all 30 cases of study group had been on therapy for a minimum of 4 months on oral tetracycline and topical clindamycin and erythromycin 30 patients were included in the control group without previous history of antibiotic therapy. Mic (Minimum Inhibitory Concentration) was performed on PA or SE isolated from skin surface of these cases. Erythromycin resistant PA and SE isolated from antibiotic treated acne patients was 43.3% (P=0.024). Tetracycline resistant PA and SE isolated from study group was 40% (P<0.0001). Clindamycin resistant PA and SE isolated from study group was 43.3%(P=0.004). Results of this study show that, incidence of resistance to antibiotics in patients undergoing antibiotic therapy for acne was higher than control group, and there is a correlation between the resistance of SE and PA and the former therapy for acne.