Investigation of risk factors of ovarian hyperstimulation syndrom in infertile patients attending infertility center of Shariati Hospital in Tehran

Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hypersitmulation (COH). Identifying risk factors of OHSS seems to be an important task because of two main reasons: increasing the incidence of infertility and the fact that around 1-7% of COH leads to OHSS. This study is a case-control study conducted in infertility center at Dr. Shariati hospital. 75 patients, candidate for assisted reproductive technology (ART), who developed OHSS after COH were selected as the case group and 120 matched patients without OHSS were selected as control group. Factors such as Body Mass Index (BMI), serum estradiol level on the day of HCG administration, presence of polycystic ovaries and patients’ age were investigated. The incidence of OHSS was higher in younger patients. The incidence of PCO in the case group (OHSS) (37.3%) was higher than that of control group (20.8%). Incidence of BMI>30 was higher in the case group as compared with the control group. The serum estradiol level on the day of HCG administration in the OHSS patients was higher than that of control group (1534±1177 pg/ml and 1124±739 pg/ml respectively). Regarding the increasing of infertility incidence and the development of new methods of COH, detecting the risk factors of OHSS plays an important role in reduction of this dangerous and even fatal disease.