Comparison of auditory Event-related potential P300 in sighted and early blind individuals

Following an early visual deprivation, the neural network involved in processing auditory spatial information undergoes a profound reorganization. In order to investigate this process, event-related potentials provide accurate information about time course neural activation as well as perception and cognitive processes. In this study, the latency and amplitude of auditory P300 were compared in sighted and early blind individuals in age range of 18-25 years old. In this cross-sectional study, auditory P300 potential was measured in conventional oddball paradigm by using two tone burst stimuli (1000 and 2000 Hz) on 40 sighted subjects and 19 early blind subjects with mean age 20.94 years old. The mean latency of P300 in early blind subjects was significantly smaller than sighted subjects (p=0.00.(There was no significant difference in amplitude between two groups (p>0.05). Reduced latency of P300 in early blind subjects in comparison to sighted subjects probably indicates the rate of automatic processing and information categorization is faster in early blind subjects because of sensory compensation. It seems that neural plasticity increases the rate of auditory processing and attention in early blind subjects.