Acetazolamide Effect on Postoperative Pain after Laparoscopic Surgery

In laparoscopic surgery CO2 is insufflated into the abdomen and may cause referred pain. So the aim of this study is to determine acetazolamide effect on postoperative pain after laparoscopic surgery. in a double blinded clinical trial, 60 patients who were going under laparoscopic surgery were divided into two groups. Before surgery 250 mg acetazolamide was administered to group A and placebo was administered to group B. Incisional pain and referred pain was measured using Visual Analog Scale (0-10) just after consciousness, 30 min after entering the recovery room, after entering the surgery ward and the day after surgery. Data was analyzed using SPSS. In both groups, 7 nephrectomy, 10 varicosel, 6 orchiopexy and 7 pieloplasty had been done. Incisional pain scores was not statistically different between two groups (P>0.05). But the referred pain was lower after acetazolamide administration than after placebo. (P<0.05) According to the results of this study, acetazolamide reduces referred pain after laparoscopic surgical procedures that are performed with abdominal insufflations of CO2.