Report of childhood disintegrative disorder in a patient with Down syndrome

Childhood disintegrative disorder (CDD) is one of the least common entities in autistic spectrum. The disorder characterized by clinically significant loss of previously acquired skills, before age 10 years, in a child with apparently normal development for at least the first 2 years after birth. Comorbidity of Down syndrome and autistic disorder is known, however occurrence of childhood disintegrative disorder in Down syndrome is scantly reported. We report a 7 years old boy with Down syndrome, whose acquired skills, such as speech ability and social interactions, were lost during a three months period.