Comparison of Effectiveness of Extra-amniotic PGE2 and High-dose Oxytocin in Induction of Abortion.

Medical and surgical methods are used for induction of abortion. Prostaglandins are used in various forms such as vaginal tabs, gels, intra-amniotic and extra-amniotic injections. The object of this study was to compare the effectivenes of extra-amniotic PGE2 and high-dose oxytocin in induction of abortion.

The study included 60 women admitted for induction of abortion in Shahid Sadoughi hospital of Yazd from 2007 till 2009. They were randomly allocated in two groups. Data was collected by a questionnaire and statistical tests such as Fisher’s exact and chi square were used for analysis of data. The success rate in PGE2 group (P=0.014) was higher than oxytocin group. The mean time of induction of abortion in PGE2 method was shorter than oxytocin method (p=0.0001). In both the two groups, the mean time of induction of abortion in dead fetuses was shorter than that in live fetuses (p=0.0001 for PGE2 group and =0.011 for oxytocin group). There was no significant difference in the rate of complications of treatment in the two groups. In both the two groups, the mean time of induction of abortion in the 12-14 weeks period was longer than 8-11 and 15-19 weeks, which was significant in the PGE2 group (p=0.001). The use of extra-amniotic PGE2 method in induction of abortion is more effective than high-dose oxytocin and by decreasing the induction period and need for currettage, hospitaliztion period and expenditure ca be decreased leading to increased satisfaction of patients.