Prognostic Value of High Sensitive C-Reactive Protein when Combined with LDL- C/HDL- C Ratio in Detection of Coronary Artery Events

High sensitive C-reactive protein (HS-CRP) has prognostic utility in patients with acute coronary syndromes and is a strong independent predictor of future coronary events in apparently healthy subjects. In this study, the prognostic value of the HS-CRP was evaluated in detection of coronary artery events when combined with serum LDL–C/HDL–C ratio. Three hundred male patients who suffered from the symptoms of coronary artery diseases were divided into three subgroups according to the number of diseased vessels (66 with one diseased vessel, 87 with two diseased vessels, and 0 with three diseased vessels). Control group consisted of 7 males who seemed to be healthy individuals (without diseased vessesl). Serum levels of HS-CRP were measured by ELISA method and those of lipid parameters by standard methods using Cobas Mira autoanalizor. The relationships between the measured variables were analyzed by Pearson tests. Comparing with the control group significant elevation were noticed in serum levels of HS-CRP in patients with coronary artery diseases in all cases (P<0.05). Also there was a significant correlation between the serum levels of HS-CRP, LDL-C, HDL-C and LDL-C/HDL-C ratio (P<0.05). A significant correlation between the number of diseased vessels and the elevated level of HS-CRP was also found (p<0.00). The direct correlation between serum levels of HS-CRP and LDL–C/HDL-C ratio and number of diseased vessels suggests that predictive value of HS-CRP in men is considerably increased when it is combined with serum LDL–C/HDL–C ratio.