Evaluation of Helicobacter pylori and laryngeal lesions in patients undergoing direct laryngoscopy and biopsy in Taleghani hospital between 2008 and 2009

Abstract Few studies have evaluated association of Helicobacter pylori with benign and malignant laryngeal lesions. The aim of this study was to evaluate the coexistence of Helicobacter pylori with laryngeal lesions in patients with laryngeal growths, admitted in Taleghani hospital. In this cross-sectional study, all patients referred to ENT ward of Taleghani hospital for direct laryngoscopy and biopsy were evaluated. Biopsied specimens were sent for histologic evaluation and PCR (Polymerase Chain Reaction) to the Research Center for Gastroenterology and Liver diseases. PCR was used to detect Helicobacter pylori in biopsied specimens. Fifty-nine patients with a mean age of 46.1±18.3 years were evaluated. 27 patients had malignant laryngeal lesions and 32 had benign laryngeal lesions. The frequency of Helicobacter pylori in the malignant and benign group was 29.6 and 15.6 percent, respectively; the difference was statistically non-significant. However, a correlation was found between malignant laryngeal tumors with male gender, alcohol consumption, smoking and opioid usage. Findings of this study failed to find an association between the presence of Helicobacter Pylori and laryngeal cancers.