Successful Hemodialysis and Renal Transplantation in Combined Factors of V and VIII Deficiencies

The prevalence of rare bleeding disorders, including combined factor V+VIII deficiency are higher in Iran than in developed countries. There are only a few reports which have been written concerning kidney transplantation in the patients suffering from these disorders.Case report: A 22-year old girl, with a known case of combined factor V+VIII deficiency, a history of bladder stone surgery, postoperative bleeding and a need for hemodialysis due to renal failure was admitted for allograft kidney transplantation. The patient received fresh-frozen plasma and factor VIII, according to individualized protocol before, during and after the course of the transplantation. The function of the grafted kidney was very good nine months post-transplantation. Only heparin was used during hemodialysis. It has been shown that allograft kidney transplantation can be performed in rare bleeding disorders with good replacement therapy without any complications.