Possibility of Applying Aversectin C on Converted Cells of Chinese Hamster Cricetulus griseus
Author(s):
Abstract:
Background
Aversectin C consists of avermectin groups. Avermectin has been reported to block secretion of the tumor necrosis factor.Methods
For investigation of its effect, different concentrations of Aversetin C consist 0.1, 0.25, 1, 5, 10, 20, 50, 100, and 500 μg/ml were studied on the growth of converted cells in Chinese hamster.Results
It was shown for the first time that Aversectin C possesses a pronounced antitumoral function. When added at non-toxic doses, it could significantly suppress cell growth. Interestingly, at high concentration of Aversectin C, cell membrane was destroyed and cell fragments were seen in the culture media. Cell death in high concentration closely resembled apoptosis phenomenon.Conclusion
Aversectin C suppresses growth of the transformed (cancerous) cells, and this suppression has cumulative effectsLanguage:
English
Published:
Basic and Clinical Cancer Research, Volume:2 Issue: 1, Winter 2010
Page:
11
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