p53 Pp53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma

Statement of Problem: Verrucous carcinoma (VC) is a rare type of squamous cell carcinoma (SCC). These two lesions have many biological and clinical differences and proper diagnosis of these tumors have has a great influence on the patient's treatment. The purpose of this study was to compare the expression of p53 and Bcl-2 in VC, SCC and pseudoepitheliamatos hyperplasia (PEH).Methods and Material In this study, expressions of p53 and Bcl-2 markers in 20 samples of paraffin blocks of VC, 23 samples of SCC, and 22 samples of PEH were examined by immunohistochemistry method. Immunoreactiv-ity was diagnosed for p53 in the nucleus and for Bcl-2 in the cytoplasm of cells and. Then, the mean of percentage of the expression of p53 and Bcl-2 was compared. The collected data were analyzed, using SPSS Ver. 7.5. For statistical analysis, ANOVA and Tukey tests were used for Bcl-2, and Kruskal-Wallis was used for comparison between of the markers. There was a significant difference in the Average mean of Bcl-2 expression between the lesions which the VC was significantly lower than the others.There was also a significant difference in the average mean of p53 expression between the lesions. T p53 and Bcl-2 are two immunohistochemical markers which can be helpful markers in differential diagnosis of VC and SCC.