Frequency of Acute Myeloid Leukemia Markers Using Flowcytometry in Urmia Imam Khomeini Hospital in One Year

Background and Üsing immunotyping in classifying leukemia is growing increasingly. This method provides useful information about proper classifying of leukemia، the prognosis and treatment of this disease. This study is conducted to determine frequency percentage of ÇD markers in patients suffering from acute leukemia who had referred to Ïmam Khomeini Hospital in Ürmia for one year. The present descriptive study was conducted in Ïmam Khomeini Hospital in Ürmia from 22 July 2008 to 23 July 2009. Random samples were taken from pediatrics and adults’ blood ward from the 119 referred patients within one year. Then، flowcytometry markers were measured، and environmental blood slide and marrow aspiration were studied. The results demonstrated that 61 of them suffered from acute leukemia، 22 cases had chronic lymphoproliferative، and 36 patients were among miscellaneous group. Ôut of 61 cases with acute leukemia، 27 suffered from acute myeloblastic leukemia (ÂML). Âmong the 27 cases with ÂML، one (3. 7%) suffered from M1، 4 cases (14. 8%) from M2، 5 cases (18. 5%) from M3، 9 cases (33. 3%) from M4، and 8 cases (29. 6%) from M5. ÇD13 and ÇD33 markers were the most frequent ones in ÂML patients. Ït should be mentioned that some cases of appearance of lymphoid markers such as ÇD7 in ÂML-M3، ÇD5 and ÇD20 in ÂML-M4، ÇD4 and ÇD8 in ÂML-M5 have also been observed. Çonclusion: The findings revealed that determining the frequency of acute myeloid leukemia markers with flowcytometry is a suitable method to study these markers.