The prevalence of antithyroid antibodies in women with polycystic ovary syndrome in Shahrekord, Iran

Polycystic ovarian syndrome (PCOS) accompanied with obesity and insulin resistance. Many findings have showen that fat tissue has an important role in creating and resisting of various disorders in PCOS. On the other hand, thyroid has an obvious and dominant role in metabolism (specially in the metabolism of lipids and carbohydrates). Both PCOS and thyroid diseases are accompanied with disruption in function of hypothalamus – pituitary –gonad axis. This study aimed at finding the relationship between antithyroid antibodies and polycystic ovarr syndrome.

In this descriptive analytical study two groups of 54 women with the age ranges of 15 to 45 years from Shahrekord, Iran were selected and consecutively were entered the study. The first group (control group), did not have any thyroid disease, systemic disorders or PCOS based on the history, physical examinations and blood tests and they did not use any medicine. The second group (patients groups), did not have any thyroid diseases and systemic disordersbased on the history, physical examinations and blood tests but they had PCOS. Antithyroid antibodies in both groups were measured and compared using K2, t test and ANOVA.

There was no significant difference in the prevalence and levels of antithyroid antibodies between PCOS group and control subjects (P>0.05). The level of (T3) and (T4) was significantly higher in polycystic ovary syndrome than in control group (P<0.05).

It does not seem that to be more prevalent than in the healthy women and it is unlikely that they have an important role in pathophysiology of the disease.