Cetuximab induced acute cardiotoxicity, A rare but severe side effect
Message:
Abstract:
Cetuximab is a monoclonal antibody that treats malignant disease by inhibiting epidermal growth factor receptors. Cetuximab has many common adverse events have been reported including infusion reactions, skin rashes, head- ache and gastrointestinal disturbances. Cardiactoxicity and cardiac complications such as heart failure (HF), myo- cardial ischaemia, arrhythmias, hypertension, and thromboembolism are some types of side effects of anticancer agents, cardiovascular complications are one of the most feared side-effects as they can increase mortality which interferes with the gain in life expectancy due to anticancer therapy. Up till now, cetuximab associated cardiotox- icity has been rarely reported in the literature.In this paper we are reporting a case of 89-year-old male diagnosed to have laryngeal squamous cell carcinoma with a history of hypertension but no history of coronary artery disease; he developed non-ST elevation myocardial infarction (NSTEMI) after receiving the loading dose of cetuximab; his case was deteriorated to develop heart fail- ure and atrial fibrillation and required admission to cardiac intensive care unit (CCU) on mechanical ventilation. Assessment of cardiac toxicity remains a critical issue in cancer management; physicians should be aware of the potential for cardiotoxicity associated with the administration of cetuximab. Before treatment with monoclonal antibodies; caution and baseline assessment are suggested for patients aged >60 years, or with cardiovascular risk factors such as hypertension, hypercholesterolaemia, diabetes, obesity, or with a history of coronary artery disease, congestive heart failure, or arrhythmias,critical monitoring of serum electrolytes (including magnesium, potassi- um and calcium) should be monitored during and after treatment.
Language:
English
Published:
Journal of Case Reports in Practice, Volume:1 Issue: 3, Oct 2013
Page:
73
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