Pachydermoperiostosis and literature review

To report two cases of pachydermoperiostosis and to improve the clinic methods of diagnosing and treating this disease. Two pachydermoperiostosis patients in Huashan hospital were reported; the laboratory tests, imaging, and pathology tests had been taken; the related literatures were analyzed. After all the tests, both of the patients were diagnosed with PDP and treated with isotretinoin and clindamycin, one of them took the knee joint synovium resection with no recurrence in the two years after the operation. The patients were diagnosed with PDP by clinical and imaging manifestations.