Evaluation of the Effect of Oral Zinc Sulfate on Burning Mouth Syndrome: A Double Blind Randomized Clinical Trial

Burning Mouth Syndrome (BMS) is a common condition that affects menopausal women and patients experience a severe burning sensation in their mouth. So far there have been no definitive treatment for this disease.
The present study was undertaken to evaluate the efficacy of zinc supplement in improving the symptoms of burning mouth syndrome.
Patients and Sixty patients were enrolled in this study; they were randomly divided to two groups. Patients in the intervention group received replacement therapy twice daily, which continued for three months. In the control group, placebo capsules, which were completely similar to zinc sulfate capsules, were administered two times daily.
Burning sensation severity in the two groups after the intervention was significantly different (P = 0.001).
It can be concluded that zinc supplement might decrease the intensity of burning mouth syndrome in patients with zinc deficiency.