Isolation of Major Active Antibacterial Compounds of Sumac Fruit (Rhus coriaria L.)
Message:
Abstract:
Background
Infectious diseases are still one of the main causes of death according to the World Health Organization (WHO) reports. Plants due to their biochemical metabolites have been considered as one of the important sources for investigation in this field. Ethnobotanical and ethnopharmacological researches are considered effective in developing new anti-infectives. Sumac (Rhus coriaria L.) has been used as an anti-infective agent by ancient Iranian medical sages.
Objectives
The aim of this study was to isolate bioactive agents of sumac epicarp with probable antibacterial activity.
Materials And Methods
Grounded epicarp of sumac fruit was fractionated with different solvents. The fractions were dried and subjected to antibacterial investigation. Ethyl acetate fraction showed the strongest antibacterial activity. This fraction was further investigated through TLC-bioautography which led to the isolation of two crystallized compounds. The structure of these compounds (1 and 2) was identified using spectroscopic techniques. Isolated compounds were tested for antimicrobial activities.
Results
Compound 1 which was named 1,2-dioxo-6-hydroxycyclohexadiene-4-carboxilic acid was isolated from R. coriaria L. for the first time. It showed antibacterial activity against Staphylococcus aureus (minimum inhibitory concentration [MIC] = 0.02%). Compound 2 which was identified as gallic acid showed weak antibacterial effects on both gram-positive and gram-negative bacteria (MIC > 0.1%).
Conclusion
This is the first report about the chemical structures of antibacterial constituents of R. coriaria L. Previous studies have shown anti-methicillin-resistant S. aureus (MRSA) activity of sumac total extract. Compound 1 as the most effective anti-S. aureus component of sumac extract would be responsible for this activity and could be the subject matter for future investigations.
Language:
English
Published:
International Journal of Enteric Pathogens, Volume:4 Issue: 4, 2016 Nov
Page:
1
magiran.com/p1651589  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!