The Effect of Statins in Treatment of Raynaud

Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology. One of the recurrent reversible manifestations of vascular involvement which is caused by excessive vasospasm of digital arteries in SSc is Raynaud’s phenomenon (RP). More than 95% of SSc patients suffer from this complication and approximately 30% of these patients will have digital ulcer (DU) yearly. DU augments dysfunction in fingertips by impairment of hand function and ischemic complications. In this case series, we want to report 6 patients with RP and DU who fulfilled the criteria of SSc16 in Mashhad, Iran. 40 mg/night of atorvostatin for 3 months was added to their standard treatment regimen. Body mass index (BMI) was calculated by body weight/ height2 formula.Statins such as atorvastatin are useful for reducing RP and DU in SSc patients. This study proved that a dose of 40 mg atorvastatin can improve the quality of the patients’ life, RP and ulcer formation.