The Expression of B7-H3 Molecule in Periodontal Diseas
Abstract:
Statement of the Problem: T cells have been shown to play a role in the etiopatho-genesis of periodontal disease. B7-H3, a costimulatory molecule, is found to be as-sociated with regulation of T cell function in some tumoral tissues, as well as auto-immune and inflammatory diseases.
Purpose
The aim of this study was to investigate the expression of B7-H3 molecule in healthy and diseased gingival tissue samples.
Materials And Method
Gingival samples were taken from 2 groups (A and B) rep-resenting periodontal health and periodontal disease, respectively. These were paraf-finized and processed to carry out immunostaining to identify B7-H3 expression. The slides were then examined under light microscope to assess the positive staining in epithelium and connective tissue. The intensity of positive staining in epithelium and the number of positive cells in the connective tissue were evaluated. Statistical analysis was done using kappa analysis and independent t-test.
Results
Kappa analysis revealed good inter-examiner agreement for both the groups (group A: 0.718; group B: 0.797). Intensity of staining in the epithelium ranged from intense to moderate for both the groups. In the connective tissue, there was a statistically insignificant decrease (p value= 0.415) in the number of positive cells from group A (mean labeling index: 50.28±26.09) to group B (mean labeling index= 41.37±25.29).
Conclusion
B7-H3 molecule has been found to be expressed in gingival tissue samples; however, it showed a statistically insignificant decrease in periodontal dis-ease group compared to healthy group.
Language:
English
Published:
Journal of Dentistry, Shiraz University of Medical Sciences, Volume:18 Issue: 1, Mar 2017
Pages:
1 to 6
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