The beneficial effects of riluzole on GFAP and iNOS expression in intrahippocampal Aβ rat model of Alzheimer's disease
Author(s):
Abstract:
Background And Objective
Alzheimers disease (AD) is a neurodegenerative disorder specified by deposition of b-amyloid (Ab) and neuronal loss that leads to learning and memory disturbances. One of the most important causes of AD is glutamate-dependent excitotoxicity in brain regions that is vulnerable to AD. According to previous reported results, it was revealed that riluzole, as a glutamate release inhibitor, could improve learning and memory in an experimental model of AD. The aim of this study was to determine the effects of riluzole on Hippocampal astrogliosis and amyloidosis in a rat model of AD.Materials And Methods
In the present study, the effects of riluzole administration at a dose of 10 mg/kg/day p.o. on hippocampal glial fibrillary acid protein (GFAP) as an astrogliosis marker and inducible nitric oxide synthase (iNOS) level in Ab (25-35)-injected rats was evaluated.Results
The results showed that in Ab (2535)-injected rats, the intrahippocampal GFAP (pConclusion
This study indicates that in rat model of AD, riluzole is able to attenuate NO synthesis with reducing hippocampal iNOS level, probably through inhibition of glutamatergic signaling pathway. Keywords:
Alzheimer's disease , Riluzole , GFAP , iNOS , beta amyloid
Language:
English
Published:
Journal of Basic & Clinical Pathophysiology, Volume:5 Issue: 1, Winter-Spring 2017
Page:
33
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