The effect of zinc on healing of renal damage in rats
Author(s):
Abstract:
Background
Several studies have previously been performed to promote kidney healing after injuries. Objectives
The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats.Materials And Methods
Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies.Results
In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries.Conclusions
Overall, Zinc can contribute to better healing of the rats kidneys after a traumatic injury.Keywords:
Kidney , Trauma , Wound Healing , Zinc
Language:
English
Published:
Journal of nephropathology, Volume:6 Issue: 3, Jul 2017
Pages:
157 to 162
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