Effect of Olanzapine and Risperidone on Oxidative Stress in Schizophrenia Patients
Author(s):
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Oxidative stress has been suggested to contribute to the pathophysiology of schizophrenia. Increased oxidative stress is the result of either an increased production of free radicals or a depletion of the endogenous antioxidants. However, whether this imbalance of oxidant-antioxidant status in schizophrenia is integral to disease itself or the effect of antipsychotic drugs is not clearly understood. The present study was undertaken to evaluate the effect of olanzapine and risperidone on oxidative stress, and anti oxidant status. A total of 179 patients were enrolled, and 93 of them completed the study. Malondialdehyde (MDA) and reduced glutathione (GSH) were measured for oxidative stress assessment. Plasma levels of ascorbic acid (vitamin C) and α-tocopherol (vitamin E) were measured for anti-oxidant status evaluation. All patients were studied at baseline, and after 3 months treatment with olanzapine or risperidone. 30 apparently healthy people were taken as control. The schizophrenia group presented higher levels of oxidative stress than the control group, as revealed by elevated quantities of the pro-oxidant MDA, and decreased levels of the antioxidants GSH, plasma α-tocopherol and ascorbic acid (P
Keywords:
Language:
English
Published:
International Biological and Biomedical Journal, Volume:4 Issue: 2, Spring 2018
Pages:
89 to 97
magiran.com/p1860124
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!