Antimicrobial Susceptibility Pattern of Six Threatening Pathogens at Mofid Children's Hospital, Tehran, Iran

The treatment of bacterial infections is increasingly complicated due to the ability of bacteria to develop resistance to antimicrobial agents. The aim of this study was to survey the antimicrobial susceptibility patterns of several pathogens isolated from in- and out-patients at Mofid children’s hospital.
From October 2015 to April 2016, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus spp. detected from clinical (urine and non-urine) specimens of inpatient and outpatient were survived. Sensitivity was measured by disc diffusion method based on the CLSI recommendation.
Totally, E. coli (62.7%) and P. aeruginosa (42.3%) were the predominantly isolated pathogens in this study from urine culture and non-urine culture, respectively. All cultured staphylococcal isolates were susceptible to vancomycin. The most effective antibiotics for Gram-negative bacteria were meropenem, amikacin, and imipenem, in sequence. None of the Gram-negative bacteria was sensitive to tetracycline.
Our findings showed that there was a considerable geographic variation in bacterial patterns and antibiotic susceptibility properties. Therefore, monitoring of antibiotic sensitivity pattern is helpful for selecting antibiotics for empiric therapy.