Therapeutic Effect of Gallic Acid Against Paraquat-Induced Lung Injury in Rat
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Paraquat (PQ), a potent herbicide, is extremely toxic to humans when exposed orally and it is known to induce lung injury via a redox cyclic reaction.
Objectives
The current study aimed at examining the effect of gallic acid (GA), a polyphenolic compound, which is a constituent of plant-derived foods, against PQ-induced lung injury and pulmonary fibrosis in association with its antioxidant activity.
Methods
Male rats were randomly divided into 5 experimental groups each containing 14 rats. Group 1 received normal saline for 21 days. Group 2 received a single dose of oral administration of PQ (50 mg/kg, only on first day) for 21 days. Groups 3 to 5 were treated with different doses of GA after PQ ingestion for 21 days. Seven animals from each group were sacrificed on the days 7 and 21.
Results
The results showed that paraquat gavage, significantly enhanced the inflammatory and fibrotic modifications, hydroxyproline (HP), levels of malondialdehyde (MDA), main proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor (TGF)-β1 as a pro-fibrotic mediator in lung tissue. It also, significantly diminished enzymatic antioxidant amounts such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity and non-enzymatic amounts such as glutathione (GSH) content in the rat lung tissue. However, after GA treatment all of these biochemical indices were diminished with a dose dependent manner and histopathological alterations were also close to normal status.
Conclusions
The current study indicated that the GA improved the PQ-induced lung injury and prevented the process of pulmonary fibrosis via its antioxidant and immunomodulatory properties.
Language:
English
Published:
Jundishapur Journal of Natural Pharmaceutical Products, Volume:13 Issue: 3, Jun 2018
Page:
3
magiran.com/p1876051  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!