An approach to Improve Therapeutic Efficacy of Doxycycline Hyclate in Treatment of Periodontitis
Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
A number of ways have been investigated for administration of antibacterial agents in dealing of plaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate an antibacterial agent. The formulations were so developed with an aim to reduce the dose of a drug, to target the drug to the specific site and to maintain dosage at its absorption site for an extended period of time thereby improves the patient compliance. The study was aim towards by formulating the periodontal in situ gels by temperature induced gelation technique with the utilization of polymer Pluronic F127 which is synthetically prepared. The Pluronic F127 showed the sol-gel transition phenomenon in between 27-37ºC. In situ gels so prepared and characterized for its physico-chemical properties, pH, gelation properties, rheology, gel strength, mucoadhesion, drug content, in vitro & ex-vivo drug release rate, texture analysis and DSC. The formulation found to be solution at room temperature and forms gel after installation into periodontal pocket hence leads to increase in retention time and slowly releases the drug into pocket. The results of characterization of formulation were found to be satisfactory and hence significant bioavailability can be increased these in situ gelling systems would be definitely useful for improving therapeutic efficacy of doxycycline hyclate in periodontitis. Owing to these properties it can be used as an effective delivery system for the intrapocket route.
Language:
English
Published:
Iranian Journal of Pharmaceutical Research, Volume:17 Issue: 4, Autumn 2018
Pages:
1550 to 1562
magiran.com/p1885679  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!