Recurrent Hodgkin’s Lymphoma with Bleeding: A Case Report

One of the rare platelet dysfunction, which is impairment of receptor GPIIb/IIIa and platelet aggregation defect, is acquired Glanzmann’s thrombasthenia. A common cause of this thrombasthenia is an autoantibody or plasma protein inhibitor against a normal GPIIb/IIIa glycoprotein. In this case report, a 28-year-old female with a history of treated Hodgkin’s lymphoma presented with a menometrorrhagia and ecchymosis. Before that, she had no bleeding history and there was no family history bleeding tendency. Laboratory findings revealed bleeding time > 10 minutes, normal partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, and von Willebrand factor. Platelet-aggregation studies showed no aggregation to adenosine diphosphate (ADP), collagen, and a normal response to ristocetin. The clinical history, medical history, and laboratory findings supported a diagnosis of acquired Glanzmann’s thrombasthenia. Imaging revealed significant lymph nodes was compatible with recurrent disease. The patient’s menorrhagia and bleeding tendency were controlled by systemic chemotherapy. This report shows the association of acquired thrombasthenia with the recurrent Hodgkin’s lymphoma, which can be controlled by remission induction chemotherapy.