Peri-operative radiotherapy for the prevention of post-operative fibrosis on rats
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Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Post-operative fibrosis related pains and functional anomalies can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats.
Materials and Methods
Twenty three male Wistar albino rats, were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats.
Results
The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups.
Conclusion
It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.
Language:
English
Published:
International Journal of Radiation Research, Volume:16 Issue: 4, Oct 2018
Pages:
481 to 485
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