The effect of haloperidol administration on relieving cluster headache, probable role of dopaminergic pathway; a double blind clinical trial
Message:
Abstract:
Background
The present study was carried out with the aim of assessing the effectiveness of 2.5 mg dose of haloperidol compared with its standard 5 mg dose in relieving symptoms of cluster headaches and finding out to what extent the dopaminergic pathway affects the incidence of cluster headaches.
Methods
The present study is a double-blind randomized clinical trial carried out in 3 health centers, Tehran, Iran. Patients diagnosed with cluster headache were treated by intravenous administration of 2.5 and 5 mg of haloperidol. Using a standard visual analog scale, pain severity was recorded before and 30, 60, 90, and 120 minutes after intervention. Treatment success (at least 3 points decrease in pain severity), side effects and recurrence of the headache were evaluated.
Results
Finally, 42 patients were treated with 2.5 mg dose of haloperidol and 41 were in the 5 mg dose haloperidol treatment group. 40 (95.2%) patients who were treated with 2.5 mg dose of haloperidol experienced a significant decrease in pain (at least 3 points decrease in pain severity) in the initial 30 minutes. During this time, all of the patients (success rate=100%) treated with 5 mg dose of the drug had a significant decrease in pain. The two doses did not have a significant difference regarding treatment success (p=0.42).
Conclusion
Results of the present study showed that both 2.5 and 5 mg doses of haloperidol have similar effectiveness in reducing cluster headaches. The high success rate observed indicates that hyperactivity of dopaminergic pathway plays an important role in onset of cluster headaches.
Language:
English
Published:
Journal of Medical Physiology, Volume:1 Issue: 2, Autumn 2016
Pages:
72 to 77
magiran.com/p324541  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!