فهرست مطالب
International Journal of Preventive Medicine
Volume:7 Issue: 10, Oct 2016
- تاریخ انتشار: 1395/08/19
- تعداد عناوین: 7
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Page 1BackgroundOrally disintegrating tablets (ODTs) are a modern form of tablets that when placed in the oral cavity, disperses rapidly. These tablets have advantages, particularly good applications for children and old patients who have a complication in chewing or swallowing solid dosage forms.
The aim of this study was to design, formulate, and evaluate the physicochemical properties of 5 mg montelukast ODTs for the prevention of asthma and seasonal allergies.MethodsFormulations were prepared with different amounts of super disintegrating agents and effervescent bases as disintegrant agents. Flowability and compressibility of mixed powders were evaluated. The prepared formulations were tested for hardness, thickness, friability, weight variation, drug content, wetting time, disintegration time, dissolution study, and moisture uptake studies.ResultsThe compressibility index and angle of repose were in the range of 15.87%23.43% and 32.9334.65, respectively. Hardness, thickness, friability, wetting time, and content uniformity of formulations were in the range of 33.737.1 N, 3.003.81 mm, 0.27%0.43%, 3150 s and 96.28%99.90%, respectively. Disintegration time of the tablets prepared with super disintegrating agents, effervescent bases, and combination of two were in the range of 3050, more than 60
and 2036 s, respectively.ConclusionsMixture of powders and tablets passed all the specified tests. The results showed formulations prepared by super disintegrating agents and super disintegrating agents with effervescent bases had shorter disintegration time compared to formulations with effervescent bases alone.Keywords: Direct compression, montelukast, orally disintegrating tablets, prevention of asthma or seasonal allergic -
Page 2BackgroundThe research to date does not present an articulated approach to ensure nutrition and food systems education is systematically implemented within schools. This paper aimed to investigate food experts views of the best strategies to improve school‑leavers knowledge of nutrition and food systems.MethodsIn this qualitative study, 28 Iranian food and nutrition experts from four major provinces (Tehran, Fars, Isfahan, and Gilan) were selected and agreed to be interviewed. Required data were collected through in‑depth, semi‑structured, face‑to‑face, or telephone interviews and were analyzed thematically using NVivo.ResultsThe experts suggested strategies to improve Iranian school‑leavers knowledge of nutrition and food systems fell into three key themes: Policy, education processes, and supportive environments. Together they formed an overarching theme of a multileveled system approach for transferring knowledge.ConclusionsDevelopment of a scaffolded education program could assist curriculum developers and policy makers to assess and update current nutrition and food systems education programs in schools. Insights gained about education initiatives in one country such as Iran can provide an important impetus to support nutrition and food system education more widely.Keywords: Education strategies, food systems, Iran, knowledge, nutrition, school‑leavers
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Page 3BackgroundFerrous sulfate is the most used supplement for treating anemia, but it can result in unfavorable side effects. Nowadays, nanotechnology is used as a way to increase bioavailability and decrease the side effects of drugs and nutrients. This study investigates the effects of nanoparticles containing iron on blood and inflammatory markers in comparison to ferrous sulfate in anemic rats.MethodsTo induce the model of hemolytic anemia, 50 mg/kg bw phenylhydrazine was injected intraperitoneally in rats on the 1st day and 25 mg/kg bw for the four following days. Then, rats were randomly divided into five groups. No material was added to the nipple of the Group 1 (control). Group 2 received 0.4 mg/day nanoparticles of iron; Group 3 received 0.4 mg/day ferrous sulfate, and Groups 4 and 5 received double dose of iron nanoparticle and ferrous sulfate, respectively for ten days.ResultsHemoglobin and red blood cell (RBC) in Group 2 were significantly higher than Group 3 (PConclusionsSingle dose of nanoparticles had more bioavailability compare to ferrous sulfate, but this did not occur for the double dose. Furthermore, both doses of nanoparticles caused lower inflammation than ferrous sulfate.Keywords: Anemia, ferrous sulfate, nanoparticle
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Page 4BackgroundTo determine the mean and median delays in pulmonary tuberculosis (PTB) diagnosis among adults in one of the worlds highest gross domestic product per capita countries and identify patient and health system‑related reasons for these delays.MethodsThis is a cross‑sectional, face‑to‑face, prospective study of 100 subjects with confirmed PTB, conducted at main tuberculosis (TB) admitting facilities in Qatar. The mean and median diagnostic delays were measured. The Chi‑square test with two‑sided PResultsThe mean and median total diagnostic delays of PTB were 53 (95% confidence interval [CI] 42.6163.59) and 30 (interquartile range; Q1Q3, 1560) days, respectively. The mean patient factor delay was 45.7 (95% CI 28.163.4) days, and the median was 30 (interquartile range; Q1Q3, 1560) days. The mean health system factor delay was 46.3 (95% CI 35.4657.06) days, and the median was 30 (interquartile range; Q1Q3, 1860) days. The most common cause of patient factor delay was neglect of TB symptoms by patients (in 39% of cases), and for health‑care system factor delay was a failure (mostly at general and private care levels) to suspect PTB by doctors (in 57% of cases). There were no significant associations between the presence of language barrier, patient occupation or nationality, and diagnostic delay.ConclusionsDespite a favorable comparison to other countries, there is a substantial delay in the diagnosis of PTB in Qatar. Relevant actions including health education on TB are required to minimize this delay.Keywords: Delay, diagnosis, pulmonary tuberculosis
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Page 5BackgroundObesity is a major problem in both developed and underdeveloped countries. The aim of this study is to investigate the effects of a physical education program (PEP) on promoting health belief model (HBM) scores, increasing physical activity (PA), and reducing obesity among Iranian high school students.MethodsThis quasi‑experimental study was accomplished at four high schools that were randomly divided into two groups of experiment (forty) and control (forty) male students in junior high schools in Urmia, Iran. Students in the experimental group received a PEP during 6 months. The essential parameters were used for evaluating the effects of educational program on HBM, PA, and body mass index (BMI) of students.ResultsAfter the intervention of 3 and 6 months, the experimental group showed a significant difference on the results of HBM constructs. According to the result of repeated‑measures ANOVA, there is a significant difference between the experimental and control groups about the components of PA constructs. Analysis of covariance showed that although BMI reduced in 6 months after intervention, there was no significant difference in BMI.ConclusionsResults of the study revealed that implementation of PEP was effective on increasing the score of the components of HBM and PA of students.Keywords: Health belief model, obesity, physical activity, physical education program
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Page 6BackgroundDue to the attribution of fatty liver with some chronic diseases such as obesity, finding a way to control obesity can be useful for the management of fatty liver. This study was performed to assess the effects of Plantago psyllium (PP) and Ocimum basilicum (OB) on anthropometric measurements in people with hepatic steatosis.MethodsAll patients with nonalcoholic fatty liver disease (NAFLD) were enrolled in this four‑arm parallel, randomized, and single blind trial. They randomly assigned into four groups receiving (1) OB 10 g/day; (2) PP 10 g/day; (3) mix of OB and PP 10 g/day; and (4) control group without placebo for 12 weeks. Anthropometric measurements were assessed during study baseline and after 12 weeks intervention. The data were analyzed using paired sample t‑test for within group and analysis of covariance for between groups.ResultsIn within group analysis, weight and body mass index show a significant reduction after 12 weeks intervention. In addition, soft lean mass and lean body mass were decreased in PP and mixed of PP and OB groups significantly; another group (OB) shows the same result for mass body fat. Although in intervention groups, we see considerable reduction, between group changes did not demonstrate the same consequences.ConclusionsThe results of this study showed that administration of OB, PP, or mix of them for 12 weeks does not affect any of the anthropometric measures in NAFLD.Keywords: Fiber, mucilage, nonalcoholic fatty liver, obesity, Ocimum basilicum, Plantago psyllium, weight
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Page 7Acquired bilateral longitudinal true leukonychia is a rare disorder. We present a case of a 35‑year‑old healthy woman presented with this unusual and rare manifestation. She mentioned a history of unprotected exposure to detergents and bleaching chemical agents. Considering her low zinc level, she was prescribed with zinc capsules and recommended to avoid chemical substances for 6 months. During bimonthly follow‑up, her zinc level turned normal, and leukonychia subsequently disappeared. Bilateral longitudinal true leukonychia in the nails due to zinc deficiency and exposure to chemical substances has not been reported previously. Direct and indirect effects of chemical substances on matrix and the effect of zinc deficiency on healing process should be considered in these cases.Keywords: Chemical agent, irritant contact dermatitis, true leukonychia, zinc deficiency