Journal of Skin and Stem Cell
Volume:3 Issue: 3, Sep 2016

In this article we are going to clarify the importance and practical role of liposomes in cosmetics.

  In pharmaceutics, we have a vast area for designing different dosage forms in order to deliver the active pharmaceutical ingredient to its site of action. However, in cosmetics, since skin is the first defensive barrier against external factors and prevents many substances from entering the underlying layers or systemic circulation, there are some limitations to deliver the active ingredient to the target site.

Therefore, we investigated the role of liposomes in cosmetics, and reviewed references in which the properties and applications of liposomes in cosmetics have been studied.

This article explains the constituents of liposomes, how they have been discovered and entered the cosmetic field, as well as their definition. Subsequently, it introduces different types of cosmetic liposomes that can be utilized in various cosmetic formulations depending on their specific properties and finally, the benefits of application of liposomes in cosmetics are taken into consideration. By using liposomes, we are able to overcome some restrictions such as low penetration, solubility, stability, duration of effect and high side effects or costs, and improve some other characteristics.

Lichen planus (LP) is a skin disease with unknown origin; however, some studies revealed that ABO blood group is correlated with LP; the current study aimed at evaluating this possible relationship.

The current case-control study was conducted on 79 patients with LP referring to Shohada-e-Tajrish and Loghman-e-Hakim hospitals as well as 79 healthy donors as the control group.

The most common type of LP was cutaneous phenotype (57 out of 79); in the patients group, the frequency of ABO blood groups was A (38%), O (36.7%), B (16.5%) and AB (8.9%), while it was O (34.2%), A (27.8%), B (26.6%), and AB (11.4%) in the control group. Blood group A observed more frequently in patients with mucosal phenotype (P = 0.012), but the correlation between LP and Rh was not significant (P = 0.3).

The results of the current study revealed that Rh has no impacts on LP. Based on the current study findings, individuals with blood group A were more susceptible to mucosal phenotype of LP

Skin is the largest organ in vertebrates that is of great importance and performs as a protective barrier against the external world. It serves various functions such as protecting against external insults, fluid homeostasis, self-healing, and sensory detection. Skin disorders impose major financial and social burden. Therefore, the regeneration potential of the skin is an important area of research in tissue engineering (TE). This potential is due to the stem cells; they play a vital role in the skin regeneration process, since one of the main characteristics of the stem cells is their ability to differentiate into the organ specific specialized cells. Numerous factors such as growth factors, topography, etc. are involved in stem cell differentiation. In the current study, primary human keratinocytes were isolated from the foreskin samples and cultured. Then, the substrate was developed using PDMS (polydimethylsiloxane) silicon following keratinocyte fixation. This substrate can be used in further stem cell culture and differentiation studies.

One of the significant signs that may occur in patients suffering from hyperandrogenism is acne. It is obvious that knowing the cause and exact reason of each sign helps the physician come up with better examination and conclusion regarding the symptoms related to hyperandrogenism.

We conducted a case-control study at the department of dermatology of Farshchian hospital in Hamadan, Iran, on 110 cases who continuously had been diagnosed with acne. The control subjects were outpatients that did not have acne but came to the clinic for consultation on dermatologic diseases other than hyperandrogenism. The patients were asked about the presence or absence of acne, age, menstrual regularity, body weight, height, hirsutism, androgenetic alopecia, family members with acne history, and food habits.

Acne was strongly associated with higher BMI, alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods. There was no association between acne and hirsutism. Some degrees of overmatching may arise from choosing dermatologic control subjects as well as from inclusion of other complaints.

BMI, Alopecia, menstrual dysfunction, positive familial history, and overuse of sweet and fatty foods may influence the risk of acne.

Dowling-Degos disease (DDD) is an unusual autosomal dominant inherited genodermatosis. It is clinically characterized by reticular pigmented macules of flexoral sites.

We reported a rare association of DDD and Hidradenitis supprativa in an Iranian middle aged woman.

A clinical and histopathologic examination showed specific features of both diseases simultaneously. Additionally, a novel treatment for this worrisome disease was discussed