فهرست مطالب عاطفه صباغ

Widespread agricultural use as well as increasing number of suicidal or accidental ingestion of paraquat in the last few years enhance the necessity to evaluate the mechanism of action and the complications, especially neuronal side-effects, of this herbicide. The aim of this study was to evaluate the histopathological alterations of the substantia nigra after paraquat intoxication in rats.
28 adult Wistar rats were randomly divided into three experimental and one control groups. Paraquat at different doses (10, 15 and 20 mg/kg) were injected intraperitoneally once a week for three consecutive weeks to experimental groups; normal saline was injected to control group. After 28 days, the brains were removed and sections from the compact part of the substantia nigra were stained by toluidine blue.
A significant enhancement of the number of dark neurons in the substantia nigra was observed in rats receiving 15 and 25 mg/kg of paraquat compared to control group.
Our findings point to the harmful effects of paraquat on neurons of the substantia nigra. This suggests paraquat toxicity as a risk factor for neurological disorders, such as Parkinson’s disease.

Pulmonary lesions of sheep are particularly important because this animal serves as one of the most acceptable source of red meat and respiratory system plays a critical role in performance of other systems. The aim of this study was to provide a regional picture of sheep lung lesions and determination of their causes as possible. For this purpose, from November 2008 to April 2009, lungs of 4592 sheep in Ahvaz slaughterhouse were examined carefully and 100 affected ones (2.18%) were found and transferred to laboratory for further investigation. Histopathological, bacteriological and parasitological studies were performed routinely on the lungs. Interstitial pneumonia, hydatid cyst, verminous pneumonia, ovine pulmonary adenocarcinoma and bronchopneumonia were the most frequent lesions (relative frequency rates were about 1.31, 1.07, 0.65, 0.5 and 0.44 percent respectively). Viruses, air pollution resulting from industrial activities and intermittent dust storm in the region must be considered as possible causes of interstitial pneumonia in sheep. Corynebacterium pseudotuberculosis was the most isolated bacteria from suppurative lesions. The most isolated nematodes were Cystocaulus ocreatus and Dyctiocaulus filaria that are different from reported species from other parts of the country.