فهرست مطالب آقای فرامرز یزدانی

Diabetic cardiomyopathy is the first cause of death in diabetic patients and angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart angiogenesis in Wistar male diabetic rats.

32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000).

The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0.05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase.

Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of diabetes.

The presence of epithelial cells in the blood is a symptom of cellular damage. Clara's cell proteins are the epithelial cells of the lungs and the respiratory tract, also, the existence of cytokines such as reactive protein C is a sign of inflammation. The purpose of the present study was to investigate the effect of one session of endurance swimming activity on the serum concentration of Clara proteins and reactive protein C in elite male swimmers. The present study was a semi-experimental research with two stage pretest and posttest design. 20 male swimmers (BMI 23/55±1/22 kg/m2, Height 174±9/12 cm, Weight 61/35±5/65 kg, fat 19/19±2/4 percent, Elite: 10 male, recreational: 10 male) participated in this study. Clara cells and reactive protein C were measured after a session of endurance activity with an intensity of 70-75% of maximum oxygen consumption for 30 minutes. Data were analyzed by repeated measures analysis of variance (P≤0/05). Statistical analysis showed that Clara's serum concentration increased significantly in both groups of elite and recreational swimmers after training intervention (p=0.001). Also, reactive protein C increased significantly (p = 0.003). The results of the comparison of the mean posttest for Clara cell and the reactive protein C of the elite and recreational groups showed that there was a significant difference in the amount of Clara cell protein (p = 0.001), and the amount of C-reactive protein (p=0.002). It seems that a session of endurance activity of the swimming-pool causes a sharp increase in the serum levels of Clara proteins and CRP in elite and recreational male swimmers, although the history was not intended.

Inroduction & Objective: Intensive exercise increase the production of inflammatory markers that can endanger the health and performance of athletes. Also quercetin is a flavonoid with antioxidant and antiinflammatory properties. Therefore, The present study was conducted to assess the effect of quercetin supplementation on CRP and IL-6, after acute resistance exercise in young men. Material and Methods: This placebo-controlled, double-blind clinical trial was conducted on 22 young men for 7 days. The subjects were randomly assigned to one of two groups to receive quercetin (1000 mg) or placebo (1000 mg dextrose). Anthropometric measurements and blood biochemical parameters including CRP and IL-6 were measured at the beginning and end of the study. The data were analyzed using variance analysis with repeated measures(2×2) and significant level was set at p ≤ 0.05. At the end of CRP and IL-6 serum concentrations in the placebo group significantly increased compared to pre-test (p<0.05). But These changes were not significant in quercetin supplements. The average of These index at the end of the study were statistically different between the two groups(p<0.05). The results of this study showed that quercetin is effective in preventing inflammation after exhaustive resistance exercise in young men.

Increasing surfactant D and Clara cell proteins (from epithelial cells of lung) in the blood is a sign of respiratory system damage. Endurance swimming is an anaerobic activity that involves activating macrophages and neutrophils. The purpose of the present study was to investigate the effect of one session of endurance swimming activity on the serum concentration of surfactant D and Clara cell proteins in elite swimmers. The present study was a Clinical trial performed in 1395 with a two stage pre-test and post-test design. The statistical sample was randomly selected from Tabriz Team swimmers (n=20), 10 elite and 10 recreational swimmers. Clara cell and surfactant D proteins were measured after a session of endurance activity with an intensity of 70-75% of maximum oxygen consumption for 30 minutes. Data were analyzed using t-test and one-way ANOVA and Tukey's post hoc test (p≤ 0.05). Clara cell serum concentration increased significantly in both groups of elite and recreational swimmers after training intervention (p= 0.001). Also, surfactant D increased significantly after training intervention only in the recreational swimmers group. Post-test results indicated that the mean value of Clara cell protein in the elite swimmers was higher than the recreational swimmers (p= 0.001) and surfactant D in the recreational swimmers was significantly more than the elite swimmers (p= 0.002). A swimming endurance session seems to increase the serum levels of Clara cellc and surfactant D in swimmers and their increase indicates respiratory system inflammation.

The risk of coronary heart disease by high blood pressure in people with hypertension and those who have normal blood pressure rises. CRP is an inflammatory biomarker for immune system and an acute phase protein. The aim of this study was to evaluate the effect of caffeine on predictive factor of cardiovascular and pressure men's blood subsequent exhaustive exercise.
Eight active men (BMI 21.55±1.22 kg/m2, Height 174±9.12 cm, weight 61.35±5.65 kg, fat 19.19±2.4 percent) were randomly selected. An hour after caffeine consumption (5 mg/kg) and a placebo in two separate sessions for each subject that are similar to Bruce test conducted 5 days. Inflammatory factor and blood pressure were measured in stages, before taking caffeine or placebo, one hour after, immediately and an hour after exercise. Data were analyzed using t-test, analysis of variance with repeated measures and with a significance level of p T-test showed that systolic and diastolic blood pressures increase by caffeine consumption, but there was no significant difference between the caffeine and placebo after exercise. However, significant differences were observed in c-reactive protein (CRP).
Consuming caffeine before exercise can increase the blood pressure higher than normal.

The purpose of the present study was to survey the effect of Neurobion supplement with exhaustive exercise of boxing on Lactic Acid, LDH, CK and CRP in amateur male boxers. 12 amateur male boxers with mean age of 19.14±2:02 years,71.35 ±6.25 weight and body fat percent 8.81± 0.65were randomly assigned to two groups of experimental and control in crossover experimental design and they consumed supplement and placebo for two consecutive weeks amount one 5cc Ampoule. The subjects performed exhaustive exercise of boxing included impact punches to boxing bag in 3 rounds with 1 minute rest between each rounds with intensity of 80-90% of MHR with polar heart measure (made of Finland) in two consecutive weeks. The investigation has done in two phases that one phase was supplement condition and placebo condition was another’s. The subject’s blood samples were collected in 4 times pretest, immediately, 2 and 6 hours after exercise for measuring lactic acid, LDH, CK and CRP levels. The results of factorial analysis showed that levels of Lactic Acid, LDH, CK and CRP were significantly lower in supplement condition compare placebo condition. Generally, consuming (B1, B6 and B12) has special affected on metabolism and enzymatic process during metabolic process and it would decrease fatigue indexes cell damage factors after an exhaustive exercise.