فهرست مطالب افسانه رادمهر

Warts are a common skin disease affecting individuals of all ages worldwide. This clinical trial aims to compare the effectiveness of furosemide 0.125 percent topical gel and KOH 10 percent topical gel in treating patients with warts.

Patients diagnosed with warts by dermatologists were included in the study and treated with either 0.125 percent furosemide or 10 percent KOH for two months. Patients were examined and imaged at the beginning of the study and in weeks 4 and 8 to assess the number, diameter, and height of warts and complications.

The study included 40 patients (48 lesions) with common warts, with 20 patients in each intervention group. In the furosemide group, the average diameter of warts decreased from 4.25 ± 1.43 mm in the first visit to 4.14 ± 1.47 mm in the final visit. In contrast, the average diameter of warts in the KOH group decreased from 3.89 ± 1.67 mm to 3.02 ± 1.49 mm. No complications were reported in the furosemide group, whereas seven complications related to redness and burning were observed in the KOH group.

Furosemide 0.125 percent is effective and safe for treating skin warts. However, it is less effective than KOH in reducing the diameter and height of warts. This study's findings suggest that furosemide can be a promising alternative to KOH in treating warts, especially for patients with sensitive skin or those who experience complications with KOH treatment. Further research is needed to determine the optimal treatment duration and dosage of furosemide for treating warts.

We can find new ways to reduce complications in treating warts.

Chronic urticaria is a skin disorder characterized by swollen pruritic plaques and papules last long at least for 6-weeks. The aim of this study was to determine the anti-TPO level in patients diagnosed with chronic urticaria, resistant to conventional treatments in order to test the possibility of thyroid hormone replacement with the aim of accelerating healing process.

In this case-control study, 63 patients with chronic urticarial and 63 controls without chronic urticarial were studied bye anti-TPO measurement. Anti-TPO level upper than 40 IU/ has been recognized as positive.

The prevalence of chronic urticaria among the case group was 3.5 times higher in women rather than men. Mean time of disease period was about 21.40±3.75 months. In this study, there was been no statistically significant association between age, sex, TSH level and anti-TPO concentration in both groups.

Anti-TPO level in patients with chronic urticaria was not significantly different from the control group. However, Anti-TPO levels were significantly higher in patients with longer duration of disease.

Dermatophytoses are the infections caused by the fungi that are capable to invade and multiply within keratinized tissues such as the skin، hair and nails. Topical azoles are considered the first-line treatment in dermatophytosis، but systemic therapy may also be required in some cases. Fungal skin infections have become more common in recent years، and injudicious use of conventional drugs has led to emergence of resistant species. This study compared the therapeutic effects of topical colloidal silver with topical clotrimazole in the treatment of tinea capitis and tinea corporis. In this double blind، non-randomized clinical trial، 40 patients with tinea capitis and tinea corporis were allocated into two groups، receiving either topical colloidal silver or topical clotrimazole، twice daily for at least 4 weeks. Systemic antifungals were also administreerd if needed. The response to treatment (negative KOH smear and resolved symptoms) was compared between the two groups at the end of the treatment period. The mean response time was 5. 26±1. 56 (range: 3-8) weeks in colloidal silver receivers and 5. 00±2. 20 (range: 3-12) weeks in the clotrimazole group (P=0. 67). The response rates were 84. 2% in the topical colloidal silver group، and 90. 0% in the topical clotrimazole group (P=0. 66). None of the patients experienced a side effect. Topical colloidal silver may be as effective and safe as topical clotrimazole in patients with tinea capitis and tinea corporis. Further studies with larger sample sizes are recommended.

Vitiligo is an skin condition that results in the skin depigmentation. The implementation of a basal cell layer suspension is a novel treatment in cases with recalcitrant vitiligo. In this study، the efficacy of topical calcipotriol on the implementation site with basal cell layer suspension versus basal cell layer suspension application alone was compared. In this randomized، controlled clinical trial، 20 patients with recalcitrant vitiligo were randomly allocated in two 10-patient groups، undergoing the implementation of basal cell layer suspension alone (controls) or along with daily application of topical calcipotriol (intervention group). Results and possible complications were compared between the two groups 6 months after initiation of the treatment. Six months after initiation of the study، 2 patients (20%) in the control group had poor responses، and 8 patients (80%) had moderate/good responses. In the intervention group، 1 patient (10%) showed poor response، and 9 patients (90%) showed moderate/good responses (P>0. 05). Complications were trivial and self-limiting. Although topical application of calcipotriol did not signigicantly change the primary outcome of the study، it was associated with better results and no major side effects.