فهرست مطالب بابک روزبهان

Breast cancer is one of the most common cancers and the first leading cause of cancer death (25.5%) among women across the world. Oxidative stress and overproduction of free radicals are among the most important reasons for the progression of cancers. This study aimed to investigate the effect of eight weeks of aerobic exercise with pomegranate juice on Serum microRNAs levels related to the oxidant/antioxidant system of women recovering from breast cancer.

In this semi-experimental study, 40 women recovering from breast cancer with a mean age of 42.45±1.95 were randomly assigned into four equal groups (n=10), including control, pomegranate juice, aerobic exercise, and aerobic-pomegranate. The aerobic and aerobic-pomegranate groups performed eight 60-90-min sessions of exercises three times a week with an intensity of 50% to 70% of the target heart rate. The pomegranate juice group received 100 cc of juice before each training session. Blood samples were collected 48 h before and after the intervention. Oncogenic microRNAs, such as miR-21 and miR-155, were assayed by RT-PCR. The obtained data were analyzed using one-way ANOVA, ANCOVA, and Bonferroni post hoc test at a significance level of P≤0/05.

In total, eight weeks of aerobic exercise with the consumption of pomegranate juice caused a significant decrease in miR-21 (P=0.001) and miR-155 (P=0.001) levels in women recovering from breast cancer, compared to the control group.

Aerobic exercise and consumption of pomegranate juice simultaneously reduced oncogene microRNAs, such as miR-21 and miR-155, in women recovering from breast cancer.

Increasing oxidative factors and reducing antioxidants is one of the main causes of breast cancer.The purpose of this study was to investigate the effect of eight weeks of aerobic exercise and pomegranate juice on serum enzyme levels related to the Oxidant-Antioxidant system of women saved from breast cancer.

In this blinded randomized control trial which was conducted in rasht in 2019, 40 women with breast cancer were selected who were randomly were assigned into four equal groups control groups (n=10), pomegranate juice (n=10), aerobic exercise (n=10) and aerobic exercise and pomegranate juice (n=10). The aerobic exercise group and the aerobic exercise and pomegranate juice group, performed training programs including 8 weeks and 3 sessions per week with intensity 50 to 70% of the maximal heart rate for 60 to 90 minutes of training. Two groups of pomegranate juice consumers received 100 cc of pomegranate juice before each training session. In order to investigate the variables of research (MDA, SOD, GPX), blood samples were collected 48 hours before and after the intervention in fasting state. The obtained data was analyzed using of one-way analysis of variance (ANOVA) and bonferroni post hoc test analysis. The significant level was P<0/05

The results showed that 8 weeks of aerobic exercise caused a significantly decreased MDA levels and significantly increased SOD and GPX levels in women with breast cancer (P = 0/0001).aerobic exercise without use of pomegranate juice, only led to a significant decrease in MDA (P=0.0001) level, and pomegranate juice consumption alone, no significant changes were observed at the three variables investigated in women with breast cancer.

According to the results, Aerobic exercise and consumption of pomegranate juice simultaneously, reduce oxidative factors and increase anti-oxidant factors in women Rescued from Breast Cancer

High level of cortisol that is concentrated due to stress expose had negative effects on health. Spiritual well-being cause positive fall and can decreases cortisol level. This study aimed to determine relationship between spiritual well-being score and cortisol level in nursing students. This was a descriptive analytical cross-sectional study that was carried out on 100 nursing students in Rasht Islamic Azad University who were training at internship in 2013. Simple random sampling based on students’ identification number was performed. We used standard spiritual well-being (SWB). Serum cortisol level was obtained at morning between 10 and 12. For statistical analysis we used independent t-test and Pearson’s coefficient of correlation. Mean of spiritual well-being and its religious and existential well-being scale were 97.8±13.4, 48.6±7.1, and 49.2±7.2, respectively. Most of students (51%) were in high level of Spiritual well-being and rests (49%) were in moderate level. Mean of plasma cortisol level was 14.08±5.08. There was no significant correlation between spiritual well-being and its subscales with serum cortisol level. Among 20 questions in Spiritual well-being scale there were significant negative correlations between cortisol level and “I believe that God is concerned about my problems” (r=-0.211, P=0.035) and “I don’t enjoy much about life” (r=-0.202, P=0.044). There was no relationship between serum cortisol level in morning and spiritual well-being scale and its subscales. However, the belief that God is a helper in problems and enjoy about life have relations with low level of serum cortisol.

Oral anticoagulants are frequently prescribed to decrease the tendency for thrombosis and embolism in susceptible individuals such as patients who underwent heart valve replacement. These components may have side effects sometimes intensify by individual and environmental factors. To investhgate the prevalence of complications of Warfarin and to determine their relationship with some individual and environmental factors in heart valve replacement patients in Guilan. This descriptive study was conducted through a prospective plan during May 2008- January 2009. The sample consists of 104 patients who underwent heart valve replacement, living across the Guilan proviance. Data were collected via a questionnaires completed by patients and results of blood test measured International Normalized Ratio (INR) Data were analyzed in SPSS using orderd regression logistic statistical method and chi- Square test. Among 936 collected records in nine stages of sampling, 56 cases (6%) showed moderate and severe increase in INR, women 1.85 times more likely to have increased INR. Among 38 cases of bleeding, 32(80%) occurred in this group of Patients, and the probability of bleeding in females was quite large (3.35). Among the factors included in this study, garlic, digestive tract medications and pain killers more likely intensify the anticoagulation effects of warfarin, increase the INR range and bleeding. On the contrary, consumption of soya, oil and cigarette smoking attenuate the drug effects on INR. With regard to results of this study that showed the effect of individual and environmental factors on warfarin therapeutic and adverse effects, it is recommended that patients underwent heart valve replacement and other user of this drug should receive necessary training and warnings.