فهرست مطالب بهجت کلانتری

Inflammation plays an important role in cancer progression. In contrast, different studies indicated that exercise training by decreasing inflammation and improving anti-inflammatory factors has positive effects in improving the condition of patients with breast cancer. The aim of this study was to investigate the effect of endurance training at low to moderate intensity on serum levels of IL-10 and IL-17 in women with breast cancer.
For this purpose, 50 patients with stage 2 breast cancer from Kerman city that completed chemotherapy courses and undergoing therapy with tamoxifen recruited and randomly divided into two groups: exercise (n = 30) and control (n = 20).Training group performed endurance training for 8 weeks with intensity between 40 to 55 percent of target heart rate .Before and after the exercise protocol, blood samples were collected from both groups and serum levels of IL-10 and IL-17 were measured using ELISA kit from Booster company. Analysis of covariance were used for detecting any alteration in variables.
Data showed a significant decrease in serum levels of IL-17 (F=2.37, p=0.015) in exercised group against control group, whereas no significant difference in level of IL-10 (F=2.62, p=0.113) was observed between control and exercise groups.
Regular moderate exercise training has anti-inflammatory and cytokine modulatory effects and through reducing serum levels of IL-17 and modulation of IL-10, plays an important role in improving the condition of patients with breast cancer.

Purposes and Breast cancer is the most common cancer among the women, 1 out of 8 women is affected by that.in case of early detection, less invasive treatments are available and also patients’ quality of life will be improved. So, we decided to analyze the prevalence of focal asymmetric density in screening mammography and sonography findings among a group of women in community. Methods and materials: This study is cross-sectional and all the women who referred to BESAT clinic in Kerman city between 23.9.2013 to 23.9.2014 for performing screening mammography were entered into the study. Of the total 900 women referred to Besat clinic, 105 women have focal asymmetric density. After sonography and easy non-random sample collection, sonography compared with mammography. people’s average age was 44±7.3 with minimum age of 29 and maximum age of 61.in sonography findings, 30 (6.28%) cases had no lesion, 2 cases (1.9 Percent) had malignancies and 73 (69.5%) cases had benign lesions.in the last group, 52 cases (49.9%) had lesions in right breast, 50 cases (47.6%) had lesions in left breast and 2 cases had bilateral breast lesions. Imaging techniques with clinical examinations are recommended for screening of the breast cancer. But with regard to limitations of sonography and mammography in diagnosis of breast cancer, in case of being highly suspicious to malignancy, biopsy should also be done.

Diagnosis of malignant lymphadenopathy is particularly important for treatment planning، staging before treatment and also for determination of prognosis. Various diagnostic procedures which are expensive and invasive are now used for distinguishing malignant from benign lymphadenopathies. Ultrasound has been proposed as a non- invasive، cost effective and available procedure compared with other procedures. This study was conducted to evaluate some ultra sound parameters in distinction between malignant and benign superficial lymphadenopathies. Lymph nodes of 100 patients who were candidates for pathological evaluation of their superficial lymphadenopathy were evaluated sonographically. The most accessible lymph nodes were marked and then biopsied and sonographic results were compared with pathologic ones، and the sensitivity and specificity of the test and the appropriate cut off point was determined based on the ROC curve and by SPSS 17. Of 100 evaluated nodes 55 nodes were benign and 45 nodes were malignant. The ratio of cortical thickness to medullary thickness was not significantly different between malignant and benign lymph nodes. There was a significant difference between blood supply pattern and average indices of PI (P=. 007) and RI (P<. 001) between benign and malignant lymph nodes. The best cutoff point of cortex thickness to differentiate malignant from benign lymphadenopathy with 62. 2٪ sensitivity and 72. 7٪ specificity and 70٪ accuracy was 7. 95 mm. The color Doppler criteria in combination with gray scale sonography can be very helpful in choosing patients for biopsy or FNA، but cannot fully replace pathological evaluation.

Several studies have shown that herpes simplex infection is the most prevalence etiologic factor for oral ulcers in patients under chemotherapy, and in leukemia.The aim of this study was to investigate the clinical characteristics of oral ulcers and their relation with herpes simplex virus infection in patients undergoing chemotherapy. This descriptive and cross- sectional study was performed on patients receiving chemotherapy in Kerman hospital in 2006. Forty one patients (31 males and 10 females) with oral ulcers were studied. The most common type of cancer was acute lymphocytic leukemia diagnosed in 20 patients. Samples were prepared from ulcers by sterile swabs and were sent to laboratory for Polymerase Chain Reaction (PCR) procedure. The obtained data were analyzed by chi- square and t- test using SPSS 13.5 program.In this study, of all patients with oral ulcers, 75.6% were men and 24.4% were women. The result of PCR test was positive in 28 cases (68.3%). Thirty patients (73.2%) had single oral ulcer and 11 cases (26.8%) were suffered from multiple ulcers. The most prevalence sites for the oral ulcers were tongue, buccal mucosa, and lip. It was concluded that the etiologic factor of oral ulcers in more than 50% of the patients under chemotherapy was herpes virus infection. Therefore, the antivirus treatment with prophylaxis should be performed for these patients. In addition, it must be considered that the clinical symptoms in diagnosis of this infection are not sufficient, and other tests such as PCR should be used.