فهرست مطالب جعفر جلالی

Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non-compartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg.min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog.

Unsaturated fatty acids are known to decrease serum leptin level. Considering that wild pistachio oil is a rich source of UFA and the reciprocal effects between leptin and thyroid hormones, the aim of the present study was to investigate the impact of dietary wild pistachio oil on serum leptin concentration and its relationship with thyroid hormones. We took 28 healthy adult male rats and divided them randomly in to the four groups group 1 a control, and the other 3 groups received a normal diet without, 5, 10 and 20% of wild pistachio oil, respectively. RIA for thyroid hormones assay (T3 and T4) and ELISA for leptin, fT3 and fT4 measurement were used. After 60 days, serum leptin levels reduced with increasing wild pistachio oil concentration in the diet in the control group with normal diet, no significant alterations were seen. This reduction also was not statistically significant in the 10% wild pistachio oil group, whereas differences between groups were significant, indicating the increasing effects of increased amounts of wild pistachio oil percent on the reduction process observed. Pearson correlation coefficients were calculated between leptin and thyroid hormones in the different sampling times. Control group did not have any significant correlation. In group 2 (fed with 5% wild pistachio oil), leptin concentration had a negative significant correlation with T4 and fT3 and a positive significant correlation with fT4 in the third stage of sampling (day 30). A positive significant correlation between leptin concentration and fT4 in the fifth stage of bleeding (day 60) was observed in group 3 (fed with 10% wild pistachio oil). In group 4 (fed with 20 % wild pistachio oil) a significant negative correlation between leptin concentration and fT3 was observed in the second stage of sampling (day 15). Wild pistachio oil has a high content of unsaturated fatty acids, and reductins in serum leptin levels in the rats studied can be due to these acids. Oral consumption of wild pistachio oil has a positive effect on reductiong leptin and LDL-cholesterol thyroid hormones and prevention of cardiovascular diseases.