فهرست مطالب جلال الدین شمس

Cancers are among the serious problems in communities. In recent years, herbal products have been very promising regarding their anti-tumor and immunomodulatin potentials. SIM5, a herbal preparation, has had good results in discriminating between cancerous cell lines and normal cells, but have not examined directly on patients cells yet. In this study, bone marrow mononuclear cells from cancerous and non-cancerous samples were used to study the effects of SIM5.
Remained bone marrow samples of multiple myeloma patients (7 cases) and individuals who clinically needed bone marrow examination, but finally were diagnosed with no serious pathologic conditions in their leukocytes (7 cases) were considered as control group. Mononuclear cells were isolated and cultured with SIM5 and R10 fraction. After 48 h incubation, toxicity was assessed using LDH release test and vital activity with MTT test.
Cell toxicity with SIM5 was observed only in multiple myeloma samples and not in control group samples. There was a strong correlation between toxicity and the number of plasma cells in bone marrow mononuclear cells. SIM5 induced a decrease in vital activity of cancerous cells but an increase in the normal bone marrow samples.
SIM5 has distinct effects on normal and cancerous cells, and its toxic effect is focused on the latter. Therefore, it possesses the properties of an ideal product to be studied more seriously.

Pomalidomide - a combination of Lenalidomide and Thalidomide drugs- is one of the newest anticancer drugs. Pomalidomide induces apoptosis in cancer cells. Furthermore, few studies indicating its relatively low cytotoxic effects on normal peripheral blood cells have been carried out. However, there is yet no information about the effects of Pomalidomide on bone marrow cells that contain important immune cells. In this study, the effect of Pomalidomide on normal bone marrow mononuclear cells was studied. The samples obtained from individuals who clinically needed bone marrow examination, but finally were diagnosed with no serious pathologic conditions in their leukocytes. Remained bone marrow aspirates were obtained and mononuclear cells were isolated. Half of the mononuclear cells were cultured with Pomalidomide (final concentration 10ìM) and the remaining half(control group) were cultured with media alone. After 48h incubation, vital activity (MTT) and cell apoptosis induction rates were assessed. The results showed that the vital activity of bone marrow mononuclear cells cultured in the presence of Pomalidomide increased significantly compared to the control group (P<0.05). However, Pomalidomide had no apoptosis induction and the rate of apoptotic cells had no significant difference with control group. Pomalidomide moderately stimulates the viability (or activity) of normal bone marrow mononuclear cells to improve and maintain them. Also, unlike most anticancer drugs it has no observable toxic effect or apoptosis induction on these cells. So, it may be concluded that Pomalidomide may be more favorable in preventing the side effects of anticancer drugs on normal cells.

The present study was an experimental design with follow-up and control group and it aimed at investigating the effectiveness of stress management and relaxation training (SMART) in reducing the Negative Affect and in improving the life quality of women with Breast Cancer. Population of the study included all the women with breast cancer who visited Mostafa Khomeyni Hospital and 18 patients were selected and were put randomly into experimental group (9 patients) and control group (9 patients) based on the inclusion and exclusion criteria. The B-SMART was administrated in 10 weekly sessions on the experimental group while there was no psychological treatment for the control group. PANAS questionnaire for Negative Affect, QLQ -C30, QLQ-Br23 questionnaires for quality of life, were completed by both groups before, after and 2 months after the program. The results obtained from the repeated measures analysis of variance showed the significant reduction of negative affect and improvement of the some life quality subscales of the experimental group in comparison to the control group which was stable during the 2 months follow-up.

The purpose of this study was to investigate the effectiveness of cognitive-behavioral stress management in reducing the anxiety, depression and stress of women with breast cancer. This study is experimental with a pretest-posttest control group design. The study population was limited to women with breast cancer who had referred to Mostafa-Khomeyni Hospital from among which 18 patients were selected and randomly assigned between two groups: experimental group (n=9) and control group (n=9). The independent variable was cognitive-behavioral stress management which was administrated in 10 weekly sessions on the experimental group while there was no psychological treatment for the control group. The research instrument was DASS-21 and HADS. The data was analyzed using covariance analysis and based on 16 patients experience surveys. Cognitive–behavioral stress management led to reduction in the anxiety, depression and stress in DASS-21 and HADS variables among patients of the experimental group (with the anxiety and depression (P<0/01) and stress (P<0/05)). Cognitive–behavioral stress management for women with breast cancer may also be used as a supplement method enhancing standard oncological treatment.