فهرست مطالب زهرا بیاتی

Breast cancer is both the prevailing malignancy and the most common cause of cancer death among women. Many factors may play a role in the susceptibility to the breast cancer and Oxygen Free Radicals may be one of these. There are various known antioxidant systems against oxidative stress, including ParaoxonaseI. The aim of this study was to investigate the association between rs854560 polymorphism in the PON1 gene in patients with breast cancer.
We performed genotyping analysis using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) assay in a case–control study of 83 confirmed breast cancer patients and 100 cancer-free controls in Markazi Province.
In our study of the PON1 gene L55M polymorphism, the LL genotype was found in 2 (2.40%) patients, whereas the LM genotype was found in 69 (83.13%) patients. The MM genotype was present in 12 (14.45%) patients. In the control group, LL, LM and MM genotypes were found in 4 (4%), 81 (81%), and 15 (15%) subjects, respectively. There was no statistically significant difference between patient and control groups in terms of the PON1 gene L55M polymorphism (p= 0.825). Allele distributions were different but this difference did not reach statistical significance (p= 0.920).
We found no association between M55L polymorphism and breast cancer.

Treatment challenges, continuous need for care, constant anxiety, and the ensuing effects lead to decreased quality of life in diabetic patients. Therefore, in this study, we aimed to investigate the effectiveness of supportive group psychotherapy in the improvement of quality of life in patients with type II diabetes. In this quasi-experimental study with a pretest-posttest design, 24 subjects were randomly selected from the Diabetes Clinic of Tafresh, Iran. The participants were allocated to two homogenous groups, based on their pre-test scores. The subjects were randomly assigned to control and experimental groups. Supportive group psychotherapy was employed in the experimental group for 10 sessions, followed by post-test. The data collection tool included World Health Organization Quality of Life-BREF. Statistical analysis was performed, using dependent and independent t-test and analysis of variance. The analysis of variance and independent t-test results showed no significant difference between the two groups in pretest (P<0.05). However, dependent t-test results showed a significant difference between the pretest and post-test scores in the experimental group (P<0.05). The results indicated that supportive group psychotherapy is effective in the enhancement of quality of life in patients with diabetes.