سعیده فرج زاده

Lupoid (LL) and chronic leishmaniais (CCL) are variants of cutaneous leishmaniasis (CL) which are resistant to various treatments. The diseases are endemic in some developing countries such as Iran. A Variety of drugs with different effects have been suggested in recent decades. Carbon deoxide laser has been recently applied in the treatment of different dermatological diseases. The aim of this study was to compare the efficacy of CO2 laser compared to systemic Glucantime plus Allopurionl in the treatment of LL and CCL. A total of 50 patients with 86 LL or CCL lesions were participated in this study. They were divided into the two groups; the first group was treated with CO2 laser for one session and the second group was treated with Glucantime (50 mg/kg IM for 21 days) plus Allopurionl (20mg/kg for 30 days). All patients were followed at weeks 4th، 8th، 48th and 72nd and the results were compared. At week 4، the cure rate of complete improvement of two treatment groups was not statistically different (P=0. 609). By week 8، the cure rate slightly decreased (P=0. 417). The decreasing trend continued until weeks 48th and 72nd (P=0. 289 and P=0. 095، respectively). Finally، 16 patients of laser group and 22 patients of the other group were cured، but statistically no significant difference was observed between the two groups (P=0. 095). Carbon deoxide laser therapy could be used in patients with hypersensitivity to pentavalent antimoniate or those with serious systemic diseases.

Background and Vitiligo is a common acquired pigmentation disorder. There are various therapeutic options for the treatment of vitiligo which bare some limitations due to their side effects. Recently topical immunomodulators (TIMS) such as topical Pimecrolimus have been used for the treatment of vitiligo in children as safe and efficient therapeutic options. This study compared the efficacy of the combination therapy of Pimecrolimus 1% cream and Mometasone cream with either agent alone in the treatment of childhood vitiligo. In a nonrandomized double blind interventional study, 50 patients were enrolled. In each patient three lesions was selected. Topical Pimecrolimus cream 1% was applied to the first lesion twice daily, topical Mometasone furoat 0.1% ointment was applied for the second lesion every night, and Pimecrolimus cream 1% and topical Mometasone ointment 0.1% were applied to the third lesion twice/daily for the first five days. Topical Mometasone furoat 0.1% ointment was used at nights for the rest of the days of the week. All three treatments were administered simultaneously over three months. The data was analyzed using SPSS V.20. Forty patients completed the study period whose mean age was 10.6 years and 46% were male. Significant decreasing trend was seen in the lesions size over time (P< 0.0001). However, this decreasing trend was not statistically significant among the three treatment groups at the end of the study (P= 0.5). In this study combination therapy had no any advantage to either Pimecrolimus or Mometasone. However, due to the limited number of patients in this study, further studies with large sample sizes are needed to evaluate the efficacy of this type of combination therapy and other combination therapies. (Clinical Trials Registry Number: ACTRN12611001165976)

Atopic dermatitis is a chronic, relapsing, inflammatory and pruritic disease with an inheritable background. Atopic dermatitis patients are susceptible to some infections including viral infections due to the underlying immunological disorders. The purpose of this study is to determine the frequency of wart in children with atopic dermatitis.This is a cross- sectional study which was performed on children aged 1-13 years in kermancity. 61 children with atopic dermatitis referring to the dermatology clinic were consecutively selected as the case group. 60 healthy subjects among the kindergarten and school children were selected as the control group. The frequency of wart was investigated in both case and control groups according to age, gender, sport, public swimming pool bath, personal habits (nail biting, finger or lip sucking) and family history.Sixty one subjects suffering from atopic dermatitis with the mean age and the SD of 62.08 ± 41.58 months (ranging 12-156) were entered in this study. The frequency of male participants was 44.3% while 55.7% of the subjects were females. Nine subjects in the group of atopic dermatitis patients and 5 subjects in the control group were affected with wart. The statistical analysis did not show any significant correlation between the two groups of the study (α2=291.1, P=0.27). From 61 atopic dermatitis children, 36 subjects had a positive family history of dermatitis, asthma, rhinitis, among whom 6 subjects had a family history of wart that was significant for the purpose of this study (X2=14, P=0.00012).The most common and frequent kind of wart was the common type and the most common site of involvement affected with wart was found to be the palmo-plantar area. In this study, there was no meaningful relationship between wart and atopic dermatitis.However, positive family background was the most important risk factor for wart.

Allergic and irritant compounds are frequent in nature, and the environmental allergic factors which can induce or exacerbate eczema are different and often unknown in different areas. The aim of this study was to determine the frequency of contact dermatitis in patients with chronic dermatitis referring to dermatology clinics in kerman. In this descriptive study, standard patch test containing 24 allergens was done for 156 cases (56 males and 69 females) with confirmed chronic dermatitis who had been referred to Afzalipoor Hospital Dermatology Clinics. Evaluation of the results was done for every case 24, 48 and 72 hours after application of the patch test. In whole, 153 positive patch tests were seen in 66 (52.8%) cases of 125 patients who had been examined. The most common allergic agent was nickel sulfate detected in 20 (13.1%) patients (17 females and 3 males). The hypersensitivity reaction to this agent was significantly more common in females than males (P<0.05). Potassium dichromate with frequency of 11.1% (12 males and 5 females) was the second common allergic agent and males showed significantly more positive reaction to this agent than females (p<0.05). There was no statistically significant difference according to the age and sex between groups with positive and negative patch test results (P>0.05). As the causative agents of contact dermatitis are different in various areas, by doing patch test in each area the allergic agents can be detected for more appropriate preventive measures and treatment strategies. In this study, the first and second common allergens were respectively Nickel and Chrome compounds. Thiorum, Cobalt, benzocaine and theazolin compounds were in the third rank.