فهرست مطالب سید رضا احمدی مهرآبادی

 Psychological problems caused by addiction or opioid withdrawal symptoms can increase the risk of re-abuse in patients receiving MMT. This study aimed to Comparison of the combined effect of methadone with sertraline or venlafaxine on mental health indicators of drug abuse patients.

 This study is a clinical trial with a pre-test and post-test design. At first, 40 patients treated with methadone were selected by voluntary sampling and randomly divided into two groups. The first group received venlafaxine and the second group received sertraline during the intervention. Patients were evaluated based on the Anxiety-Stress-Depression Questionnaire. Data were analyzed using paired t-test and analysis of covariance at the significance level of 0.05.

 Findings showed that sertraline and venlafaxine effectively affect mental health dimensions, including depression, anxiety, and stress, in patients undergoing MMT (P<0.001(. No significant difference was observed between the effect of sertraline and venlafaxine on depression, anxiety, and stress in these patients ((P<0.05).

 Venlafaxine and sertraline can be used to improve the mental health dimensions of patients undergoing MMT, and due to their similar efficacy, drug selection can be based on the psychiatrist's decision and the extent of drug side effects.

Psychological problems can reduce the effectiveness of opioid withdrawal, so complementary therapies are used to increase the effectiveness of treatment in these patients. In this study, the addition of the "compassion-enriched acceptance and commitment" psychotherapy method to Venlafaxine to control depression, stress, and anxiety in opioid addicts receiving methadone maintenance treatment (MMT) was investigated.

This study is a clinical trial with pre-test and post-test design. Forty opioid addicts treated with MMT were selected by voluntary sampling method and after matching were divided into two groups (n=20), including Venlafaxine alone and Venlafaxine in combination with compassion-enriched acceptance and commitment. Patients were evaluated on the DASS21 anxiety-stress-depression questionnaire. Data were analyzed using chi-square, paired and independent t-tests, and analysis of covariance with a 95% confidence interval.

Findings showed that both intervention methods were effective on depression, anxiety and stress (P<0.05). However, combination therapy of compassion-enriched acceptance and commitment therapy with Venlafaxine had a greater effect on depression, anxiety, and stress in patients undergoing methadone maintenance treatment (P<0.05).

Adding compassion-enriched acceptance and commitment Psychotherapy to Venlafaxine improves the control of depression, anxiety, and stress in opioid addicts under MMT and can be used as an effective method in the treatment of mental disorders in these patients.