فهرست مطالب شاهین ریاحی ملایری

In the article published in volume 33, issue 226, 2023, the title was published incorrectly, which is now corrected.

Background &

Brain tumors are one of the deadliest malignancies that can directly affect the brain, and are often accompanied by executive function and memory disorders. The aim of this research was to investigate the effectiveness of endurance exercise and nano curcumin consumption on short-term memory of rats with glioblastoma multiforme brain tumor.
Materials &

In this experimental study, 35 healthy male Wistar rats were randomly divided into seven groups of five including: the basic healthy control group, 4-week healthy control, basic cancer control, 4-week cancer control, cancer + nano curcumin group, cancer + exercise, and cancer + practice + nano curcumin. One week after the injection of cancer cells into the frontal cortex, the animals entered the main exercise program on the treadmill (4 weeks, 18 m/min, and 3 days a week). In the end, the rats were sacrificed, the data were collected, and the results were analyzed using one-way analysis of variance and Tukey's post hoc statistical tests.

The results showed that endurance exercise and nano curcumin consumption significantly reduced the tumor volume in the cancer + exercise + nano curcumin group (P= 0.001), and also caused a significant increase in short-term memory in the studied groups compared to the 4-week cancer group (P= 0.001).

Probably, performing endurance exercises along with the use of nano curcumin can improve short-term memory in rats with brain tumors, in addition to reducing tumor volume.

NRF1 and TFAM are proteins that affect mitochondrial biogenesis and play an important role in diabetes. The aim of the present study was to investigate the effect of high intensity training (HIT) training and beetroot consumption on NRF1 and TFAM in visceral adipose tissue of aged type 2 diabetic rats.

In this experimental study, 40 male rats (weight range 270-300 grams and age 12-14 weeks) diabetic with streptozotocin were randomly divided into 5 groups (healthy control, diabetic control, supplement, exercise, exercise + complement) were divided. The training groups were subjected to intense interval training with an intensity of 50 to 90% of the maximum speed for 4 weeks and 4 sessions each week and 44 minutes each session. The groups receiving the supplement received 10 mg of beetroot per kilogram of body weight daily for 4 weeks and 4 times a week orally. The data are statistically significant using two-way ANONA test and (P < 0.05) was evaluated.

The results of the study showed that the induction of diabetes led to a significant decrease in the protein levels of NRF1 and TFAM, so that in the exercise group, beetroot had a significant effect on the changes of NRF1 in the visceral fat tissue of elderly rats with diabetes. (P=0.001), but the interaction of HIT training and beetroot supplement in NRF1 changes is not significant (P=0.56) and also the factor of exercise and beetroot supplement, as well as the interaction of HIT training and beetroot also has a significant effect on TFAM changes in visceral adipose tissue of elderly rats with diabetes. (P=0.001).

Based on the findings of the present research, it seems that high interval training with beetroot consumption can lead to an increase in NRF1 and TFAM gene expression and thus help to improve and control diabetes in the elderly.

Apelin as an adipokine is secreted from adipose tissue and affects various physiological processes, including the modulation of cardiovascular function, glucose homeostasis. The aim of this study is the effect of eight weeks of aerobic training and green tea supplementation on apelin and fat profile.

In this research, 32 overweight and obese non-athletes (age: 25-35 years old) in District 4 of Tehran were included in the study in four groups of 8 people including green tea and exercise group, green tea group, exercise group and control group. The training program was three days a week for 8 weeks and there was 48 hours of rest between sessions. The dose of green tea supplement was 3 capsules of 450 mg green tea extract per day after 3 main meals, breakfast, lunch and dinner. Then the serum level of apelin, total cholesterol, HDL, LDL, and BMI were determined before and after the study in the groups. Data analysis was done with SPSS 25 software and covariance test was used to compare the averages of the groups.

The findings of the research showed that eight weeks of aerobic training and green tea consumption had a significant difference on the effect of apelin in the studied groups compared to each other (P=0.043). Eight weeks of aerobic exercise and consumption of green tea did not have significant differences on cholesterol levels in the studied groups compared to each other (P=0.933). Eight weeks of aerobic training and consumption of green tea had a significant difference on (P=0.038) HDL and (P=0.012) LDL in the studied groups.

According to the results of the present study, it seems that aerobic exercise along with green tea consumption reduces apelin levels and improves the body composition and fat profile of overweight and obese women.

Regular exercise training with different volumes bydate palm pollen extract is an effectives strategy in improvinggene expression and neuromuscular function. The purpose ofthis study was to determine the Effect of four weeks ofincreasing resistance training with date palm pollen extract onthe gene expression of CHRN-G and Semaphorine-a3 in theGastrocnemius muscle of healthy male rats.

This is an experimental study. Forthis purpose, 42 six week old healthy of male rats were dividedinto 6 groups of numbers 7; Control (C), Resistance training(TR), Testosterone (T), SUP (S), Resistance training withextract (RT+SUP), Resistance training with Testostrone(RT+T). Extraction was performed with 90% ethanol at a rateof 670 ml and repeated three times. The extract wasconcentrated in vacuo and the solvent was completelyremoved. The extraction efficiency was 87.17%. Consumptionof the extract at a dose of 100 mg / kg per day to the extractgroups and exercise with the extract was gavagedintraperitoneally. Testosterone at a dose of 2 mg / kg per daywas injected into the testosterone and testosterone traininggroups.increasing resistance training, extract and testosteroneinterventions were performed for five days a week for fourweeks. After 24 hours the last training session and afterwardrecovery, subjects were sacrificed and their gastrocnemiusmuscle was extracted. PCR Real time was used to determinethe expression of CHRN-G and Semaphorine-a3 genes. tocompare the groups independent Two way anova was used atalpha level of 0/05.

genes expression of CHRN-G in the training withextract group (P=0.024) and training with testosterone(P=0.045) respectively showed a significant decreasecompared to the extract group. Semaphorine-a3 of gene in thetraining with extract group (P=0.016) respectively showed asignificant decrease compared to the extract group. Weight didnot significantly change in any of the groups.

It seems that possibly 4 weeks of increasingresistance training with consumption of date palm male pollenextract can improve neuromuscular function by reducing theexpression of CHRN-G and Semaphorine-a3 genes in thepresynaptic space.

Exercise activity has been shown to affect the concentration of leptin-affecting hormones such as insulin, cortisol, sex hormones, catecholamines, and growth hormone by altering leptin levels. The aim of this study was to compare effects of two combined training methods and ginger consumption on weight and anorexinergic hormones in overweight women.

The study was performed on 32 overweight women aged 30-45 years with a body mass index (BMI) of 25-30 kg/m2. The subjects were randomly divided into four groups of resistance training, resistance training + high intensity interval training (HIIT), HIIT + resistance training and HIIT. All subjects received 250 mg of ginger supplement daily, four times a day for eight weeks. The subjects performed HIIT at 80-90% of target heart rate in form of jogging, 35 minutes a session, three sessions a week for eight weeks. Subjects in the resistance training group performed eight weeks of training at 40-50% of one repetition maximum with 20-35 repetitions. Fasting blood samples were taken at baseline and 48 hours after the last training session. All data were analyzed with SPSS software (version 24) at 95% confidence interval using analysis of covariance and paired t-test.

Findings showed that eight weeks of combined training and ginger consumption were not significantly different in leptin, cortisol and fat profile and body mass index of women (p> 0.05). However, there was a significant difference in the ratio of WHR and insulin to insulin resistance of overweight women (p <0.05).

It seems that the combined training method (resistance + HIIT) has a significant effect on WHR compared to other training protocols and it is recommended to use combined exercise for weight loss.

The use of supplements, herbal extracts, and exercise training for the treatment of diseases and metabolic disorders has increased among people. The purpose of this study was to the Effect of Aloe vera Intake and eight-week aerobic training on serum vaspin, Glucose and serum Insulin in diabetic type 2 Women.

In this quasi-experimental study 32 diabetic type 2 Women participated and They were randomly divided into Four groups control, supplement, training , training + supplement. Training program was performed during 8 weeks (3 sessions per week, 60 min per session). The subjects consumed a supplement group of 400 mg of Aloe vera daily for 8 weeks. Ben Fonney's post hoc test and covariance analysis test were used to examine the ingroup differences and between the research groups.

The results showed that eight weeks of aerobic and supplementation of aloe vera significantly decreased vaspine, fasting glucose, insulin, insulin resistance, BMI and fat percentage in diabetic type 2 Women (P = 0.001). Quicki and VO2max also significantly increased (P = 0.001).

Implementing Simultaneous consumption of Aloe vera supplementation and aerobic training have protective effect on diabetes– induced complications in diabetic type 2 Women.

Exercise Training and selenium is an effective way to strengthen the immune system. The purpose of this research is the effect of interval training and nano selenium supplementation on the expression of testicular HSP70 and PGC-1α genes in dexamethasone induced rats. 40 Wistar rats aged 10 weeks were randomly divided into 5 groups of 8 (healthy, under dexamethasone induction (patient), patient + interval training, patient + Nano selenium supplement, patient + interval training + consumption Nano selenium supplement) were divided. The exercise program consisted of 5-12 repetitions of 1-minute running on the rodent treadmill with an intensity of 24-30 m/min, equivalent to 75-100% of maximal oxygen consumption, with active rest intervals of 75 seconds. These exercises were performed six days a week for four weeks. The prepared selenium nanoparticle solution, 100 mg in 250 nm size, was given to mice by gavage every other day. Three-way analysis of variance was used to determine the difference in variables between groups at a significant level (P<0.05). All statistical calculations were done using Excel and SPSS version 25 software. The results obtained from the research showed that interval training led to a significant increase in HSP70 (P<0.05). Also, the expression of PGC-1α gene in the group of Nano selenium supplementation and interval training led to a significant increase (P<0.05). According to the present study, it seems that interval training and Nano selenium supplementation leads to a significant increase in HSP70 and PGC-1α, which plays an important role in improving the immune function of patients with weak immune system.

Fatty liver disease is the most important reason for chronic liver diseases, from simple fatty liver to advanced stages such as liver fibrosis, cirrhosis and liver cancer. In this study, the effect of moderate intensity endurance exercise and probiotic consumption on MMP 9 gene expression in an animal model of steatosis was investigated. This study is an experimental study of laboratory type. 32 male Wistar rats were divided into 4 groups of 8: healthy group, fatty liver group, fatty liver + probiotic group, fatty liver + probiotic group + moderate intensity endurance exercise and were tested for 8 weeks. Endurance training was done for 8 weeks, 5 days a week, at 18-28 meters per minute. The statistical calculation of this study was done using the one-way analysis of variance test and, in case of a significant difference, the Bonferroni post hoc test to determine the location of the difference between groups was done with SPSS 25 software. Endurance training and probiotic consumption have a significant difference on the expression of the MMP-9 gene in the animal model of fatty liver (P=0.000) and decrease the expression of MMP-9. According to the results of the study, it seems that endurance training along with probiotic consumption can make patients with fatty liver resistant to the damage caused by this disease.

Exercise training and the use of medicinal plants are helpful in the prevention and treatment of diabetes. The purpose of this study was to evaluate effect of eight-week high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats.

In this experimental study, 32 diabetic Wistar rats with STZ (weight of 240-260 grams and an average age of 12 weeks) were randomly divided into four groups, including the “control group”, the “training group”, the “supplement group” and the “training + supplement group”. Training group was exposed to high-intensity interval training with %90 VO2max intensity for 8 weeks and 5 sessions per week for 2 to 6 minutes per session. Supplement group received 300 mg of Aloe vera daily for 8 weeks, five times a week. Data were analyzed using one-way ANOVA.

Eight weeks of high intensity interval training with Aloe vera supplementation resulted in a significant increase in adiponectin and insulin in diabetic male rats (P<0.05). But there was no significant difference in glucose and beta cell function (P>0.05).

According to the findings of the present research, it seems that high intensity interval training along with Aloe vera supplementation may help to increase adiponectin and insulin and also improve diabetes control.

In recent years, because of improved screening diseases due to inactivity, various physical activity has been proposed as solutions has justified the requirement of preventive of strategies such as lifestyle. Obesity and overweight are one of the growing problems of todaychr('39')s society and threatens the health situation around the world (1). The physical, psychological, social, and economic effects of obesity have made it one of the most complex health problems of our century, and the number of obese people in the world continues to rise (2,3). The phenomenon of obesity and overweight affects all races and age groups and sexes, given that obesity itself can cause various diseases such as hypertension or fatty liver, the effects of adipokines secreted by adipose tissue are more colorful. Visfatin is an adipocaine that is mainly secreted from visceral adipose tissue and increases in humans and obese animals. In this case, the global focus on medicinal plants is increasing day by day because it may have fewer negative effects (4,5,6). Ginger is widely used as a spice around the world. In the past, this plant was used as an important part of Chinese medicine, Indian medicine and Greek herbal medicine for the treatment of neurological diseases, colds, rheumatism, gingivitis, toothaches, asthma, stroke, constipation and diabetes (11,12,13). A comparison of two methods of parallel training and ginger consumption on visfatin and metabolic syndrome indices of overweight women was performed.

This is a quasi-experimental study with a pre-test and post-test design. 32 overweight women with an average age of 30-45 years from Tehran, located on 15 districts, randomized divided into four groups of 8, including resistance training and Ginger consumption, resistance training + high intensity training and ginger consumption, high intensity training + resistance training and ginger consumption and high intensity training and ginger consumption were divided. Subjects participated in a parallel exercise program (two groups) for 8 weeks, three sessions per week and each session for 35 minutes (19,20). All subjects consumed ginger in 250 mg capsules for 8 weeks while maintaining a consistent dietary calorie intake in four meals (21). Blood samples were taken 24 hours before the first training session and 48 hours after the last training session. After performing the last training session and 48 hours after it, as in the pre-test stage, the subjects in 4 groups in the night fasting position, blood sampling and related measurements were performed again. Immediately after blood sampling, blood samples were poured into the Falcon tube to coagulate, then the blood samples were placed in a centrifuge and the device was turned on at 3000 rpm for 10 minutes. After this time, the tubes were removed from the device and the serum was removed. Blood samples were stored in the freezer -70 until the relevant tests were performed. To measure visfatin, visfatin kit (human visfatin C-terminal made by Phoenix USA) with a coefficient of variation of 2.5 and a sensitivity of 1.2 ng / ml and the catalog number cat. No: E0025 Hu and the ELISA reader were used.Insulin was measured using a diaplus kit made in the USA with a sensitivity diaplus kit made in the USA with a sensitivity of 0.25 and a catalog number of 1606.15. Also, the amount of fasting blood sugar by enzymatic colorimetric method with the help of glucose oxidase (glucose kit, Pars Azmoun company) with a change coefficient of 4.7 was used. Insulin resistance was calculated using resting concentrations of glucose and insulin and using the formula 405 / plasma glucose (mg / dL) plasma insulin. Measurement of fats and lipoproteins using HDL measuring kit (manufactured by Mercodia, Sweden with a sensitivity of less than 1 mg per deciliter and calorimetric method), cholesterol (manufactured by Pars Azmoun Iran with a sensitivity of 3 mg / dL) Enzymatic (triglyceride) (manufactured by Pars Azmoun Iran with a sensitivity of less than 1 mg / dl and photometric method) and LDL kit (manufactured by Pars Azmoun Iran with a sensitivity of less than 1 mg per liter of photometric method) were performed. To measure height, Seca 786 height tester was used, to calculate fat percentage and body mass index, Tanita body composition device made in Turkey and also to estimate the maximum oxygen consumption, Rockport test was used. All data were analyzed using SPSS software version 24. Confirmation of data normality was obtained through Kolmogorov-Smirnov test. Therefore, to compare intergroup changes and intra group changes, analysis of covariance and paired t-test were used and alpha was considered at the level of 0.05, respectively. Data were analyzed using analysis of covariance and dependent t-test.

The values of the studied variables in the present study in two stages of pre-test and post-test in the 4 groups studied and also the number of changes within the group (changes of each group compared to the pre-test stage) Findings showed that eight weeks of training and consumption of ginger had a significant increase in visfatin levels, insulin resistance in overweight women decreased significantly (p<0.05). However, it had no significant effect on fat profile and body mass index in women (p>0.05).

The main finding of the present study was that despite the increase in visfatin, decrease in insulin and insulin resistance and WHR, no significant changes were observed in overweight individuals. Based on the research background, the results are contradictory in the effects of two parallel training methods associated with ginger consumption. On the other hand, according to the findings of this study, the two methods of parallel exercise and ginger consumption could not change the cholesterol level in overweight women. Also, the results showed that two methods of parallel exercise with ginger consumption on lipid profiles (HDL, LDL, TG) and cholesterol in overweight women has no effect. The findings of this study on the ineffectiveness of the two methods of parallel training and ginger consumption on triglycerides are not consistent with the findings of many animal studies. It seems that the parallel training method (resistance + periodic) compared to other training protocols reduces some It is more effective than indicators of metabolic syndrome.

Neurological, metabolic and physical problems such as cardiovascular insufficiency are of the most important causes of deaths in children with Down syndrome. The aim of this study was to evaluate omega-3 intake along with eight weeks of swimming training on irisin and body composition in obese girls with Down syndrome.  

In this semi-experimental study, 18 girls with Down syndrome (12 ±2 years and 22± 1.3 kg / m2) were randomly divided into two groups of exercise training and exercise training + supplements. The subjects participated in twenty-four sessions of swimming training with an intensity of 45-65 percent maximal heart rate and consumption of 300 mg omega-3 capsule (exercise group + supplement) for 8 weeks. Blood samples were taken 24 hours before the first training session and 48 hours after the last training session. Data were analyzed using repeated measures ANOVA. P≤ 0.05 was considered statistically significant.  

The results showed that in the supplementation group, the levels of serum irisin and muscle mass significantly increased after 8 weeks (P <0.05) and the amount of fat significantly decreased (P <0.05). 

 It seems that swimming training and omega-3 supplement in children with Down syndrome can reduce the risk of cardiovascular diseases and improve many of their motor limitations by affecting body composition.  Funding: This research was funded by East Tehran Branch, Islamic Azad University, Tehran, Iran.

Aerobic exercises along with the use of herbal supplements are an effective way to control the complications of diabetes. The aim of this study was to study the effect of Stevia Oral consumption and aerobic exercise on fat profile and insulin resistance in type 2 diabetic men.

In this study, 28 men with type 2 diabetes were selected for purposeful and randomly divided into 4 groups of 7, Including aerobic exercise group, stevia consumption group, aerobic exercise group + stevia consumption and control group were divided. The exercise protocol was conducted for 8 weeks and 3 sessions each week, each session being 20-45 minutes. The outcome data was analyzed using Dependent T-test and Analyze of Covariance.

There was  a significant difference between the level of pre-test and post-test of HDL, LDL, cholesterol, fasting blood glucose, triglyceride, insulin resistance, insulin resistance and maximum oxygen in the two groups of aerobic exercise and aerobic exercise + Stevia supplements compared to the two groups of Stevia supplements and control (P≤0.05) LDL, cholesterol, fasting blood glucose, triglyceride, insulin, Insulin resistance, decreased and HDL and maximal oxygen levels increased (P≤0.05).

According to research, aerobic exercise appears to decrease cholesterol, insulin resistance, fasting blood sugar and triglycerides, but intake stevia supplements has little effect on related variables.

Citrulline Malate (CM) has proposed as a supplement which improves anaerobic performance. The purpose of this study was to assess the short-term effect of CM on LDH and Lactate levels and resistance exercise performance.

In a crossover study, 16 males (mean Age: 26.4±4.7 years, BFP: 15.4±6.7 %, and BMI: 23.7±2.8 kg.m2) selected as subjects. The subjects were attended 3 resistance exercise sessions in a full body protocol consisting of Hack Squat, Leg Extension, Barbell press and Lat Pull down respectively. An hour Before the beginning of exercise, the subjects consumed 6g CM+250ml water in the first week, placebo consisting of 5g Dextrose+250ml water in the second week, and 8g CM+250 ml water in the last week. Blood Samples were taken from each subject 1 hour before, immediately, and 30min after exercise to measure LDH and Lactate levels. Immediately after each set, rate of perceived exertion (RPE) for all exercises were recorded.

There are no significant changes in Lactate levels between resistance exercise sessions (P>0.05), but there is significant difference in LDH levels (P<0.05). Moreover, no significant change seen in RPE between sessions (P>0.05).

It seems that consuming CM following an intense resistance exercise session may reduce LDH levels but it does not improve RPE after exercise.

Obesity is a complex disorder, which is characterized by excessive accumulation of adipose tissue. Leptin is a peptide hormone, which is basically secreted by adipose tissue and is effective in the regulation of body weight and fat. The purpose of this study was to investigate the effect of high-intensity interval training on the level of Leptin and liver enzymes in obese and overweight males. In this semi-experimental study, 22 males with the mean age, height, weight, and body mass index of 12-14 years,164.43±5.11cm, 74.02±12.34 kg, and 29.27± 4.09, respectively, were selected voluntarily and randomly divided into experimental (n=11) and control groups (n=11). The experimental group was subjected to 8 weeks training program (three 40-min sessions each week) which included 10 sets of cycling on a cycle ergometer for 60 seconds with 80 % intensity of the reserve heart rate. Blood samples were taken 24 and 48 hours before and after the training, respectively, in a fasting condition. Leptin, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), and Alkaline phosphatase (ALP) were measured using specific methods. Body fat percentage, body max index,  and maximum volume of oxygen were evaluated before and after the training. ANOVA was utilized to analyze data.


According to the results, there was a decrease in the levels of ALT and  body fat percentage as well as an increase in the maximum volume of oxygen in the experimental group, compared to the control group (P<0.05(. Moreover, the levels of Leptin, AST, and ALT decreased; however, the difference was not statistically significant) P<0.05(. Ethics code: IR.IAUETB.1395.52005 High-intensity interval training on a cycle ergometer can be an appropriate exercise strategy to reduce the plasma concentration of ALT and body fat percentage in obese and overweight males. However, the intervention should be longer to achieve desired results.

The use of supplements, herbal extracts, and exercise training for the treatment of type 2 diabetic has become widespread nowadays. The purpose of this study was to evaluate the effect of endurance training and resveratrol consumption on IL-10 and TNF- α in type 2 diabetic rats. During this experiment 32 diabetic rats with high-calorie diet Sprague Dowley race with an average weight of 250 ±10 gram, were randomly divided into four groups, including the “control group”, the “supplement group”, the “training group” and the “training + supplement group”. For up to 8 weeks, the “training” and the “training + supplement” groups participated in 3 endurance training sessions weekly; each session included 30 minutes of endurance training with an intensity of 70 to 75% VO2max.  Moreover, the “supplement” and the “training + supplement” groups were given 10 milligram daily doses of resveratrol consumption solution per kilogram of body weight. The outcome data was analyzed using one-way analysis of variance (ANOVA) with significance level of (p≤0.05). The results have shown that eight weeks of training and resveratrol consumption had no significant effect on the serum level of IL-10. but the level of TNF-α, Fasting Glucose, Insulin and insulin resistance decreased significantly in the groups (p= 0.001). Based on the findings of this study, the combination of resveratrol supplementation and endurance training can reduce the inflammatory factors of type II diabetes.

present study was conducted to aim of investigate the effect 10 weeks high intensity interval training on serum levels of resistin and insulin resistance in overweight and obese males. Eighteen young men with average age of 20.5±2.15 yrs. and body mass index (BMI) 28.7±2.95 kg/m2 randomly divided in two groups (each group nine person) including control and high intensity interval training (HIIT) groups. Subject in HIIT group take part in training program for 10 weeks and three sessions per week (10 bouts of one minutes running). Exercise session intensity was 80-90 percent of target heart rate. 48 hours after last exercise session, fasting blood samples collected and serum levels of resistin and insulin resistance was measured. Data were analyzed by analysis of covariance and paired t test respectively and significance considered as p

 Swimming training and garlic intake can be a preventing factor in coronary artery disease. Therefore, the aim of this study was to examine eight swimming exercises and garlic consumption on serum intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) values in obese male rats. In this experimental study, 28 male Wistar rats (mean weight 281 ± 5.9 gr) were randomly divided into four groups (control, garlic supplementation, swimming training,swimming training + garlic supplementation). Then, the training group received training sessions for 8 weeks, 3 sessions per week, and the supplemented groups + supplementary supplement received 1 ml of garlic solution per kilogram of body weight per day. Data were analyzed using one-way analysis of variance and significant level (P ≤ 0.05). The findings showed that eight week training and intake garlic on the ICAM values of the rats significantly decreased. (P <0.05). However, there was no significant effect on the VCAM values of the male rats (P <0.05). It seems that the combination of two factors of swimming training and supplementation of garlic extract or exercise alone leads to a reduction in the levels of adhesive molecules and it is recommended to use it. However, in order to determine its impact, we need more research in human samples.

  Nowadays, the effect of exercise training and Aloe Vera supplement on diabetes has been identified, but the simultaneous effect of them on diabetes is unknown. Therefore, the aim of present study was to investigate the effect of eight weeks of high intensity interval training (HIT) and moderate intensity interval training (MIT) along with Aloe Vera intake on serum levels of chemerin, glucose and insulin in streptozotocin (STZ) induced diabetic rats. In this experimental research, 32 males diabetic Wistar rats induced with STZ injection, were randomly assigned into four groups including diabetic, Aloe Vera (300 mg/kg), HIT+Aloe Vera supplement, and MIT+Aloe Vera supplement. Exercise training program was performed for eight weeks. Each exercise session consisted of 6-12 two-minute bouts (40 m.min-1 in HIT group and 25 m.min-1 in MIT group) that each bout followed by one-minute active rest. Chemerin and insulin levels were measured by ELISA method and data were analyzed using one-way analysis of variance and Tukey’s post hoc test. The results indicated a significant decrease of chemerin levels in the MIT group compared to the diabetic and HIT groups (p>0.001). Moreover, significant increase of serum insulin levels was observed in the HIT group compared to the other groups (p<0.001). Insulin increase in the supplement group was also significant compared to the diabetic and MIT groups (p<0.001). But, glucose changes were not statistically significant (p>0.05). It seems that exercise training along with Aloe Vera supplement is effective in the improvement and control of diabetes, and probably this effect is due to the decrease in chemerin or increase in insulin levels

Adiponectin and resin; Adipocytokine relateted with insulin resistance. The purpose of this study was to the Effect of eight-week high intensity interval training and resveratrol intake on Serum Adiponectin and resistin in type 2 diabetic rats. During this experiment 32 diabetic rats with High-Dieting Diet Sprague Dowley race with an average weight of 250 ±10 grams and an average age of 10 weeks, were randomly divided into four groups, including the “control group”, the “supplement group”, the “training group” and the “training and supplement group”. For up to 8 weeks, the “practice” groups participated in 5 training sessions weekly; session was 18 minutes under the influence of High-Intensity Interval training with an intensity of 90 to %100 VO2max. moreover, the supplement groups were given 10 milligram daily doses of resveratrol intake solution per kilogram of body weight Gavage was given for 8 weeks and three times a week. The outcome data was analyzed using one-way analysis of variance and significance level of (P≤0.05). The results showed that eight weeks of exercise and resveratrol consumption increased on serum adiponectin, but did not have a statistically significant effect (P = 0.62). However, serum resistin decreased and significantly affected the training group (P = 0.001). Also, the mean values of fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P = 0.001). It seems high intensity interval training with resveratrol intake can lead to glucose control in type II diabetes by changing its insulin resistance factors.

Omentin is an adipokine that is primarily secreted from visceral adipose tissue and its metabolic function is enhancement of insulin with stimulated glucose transport. The aim of this study was to investigate the effect of eight weeks of moderate intensity interval training on omentin levels and insulin resistance index in obese girls. 18 female obese students (12-14 years old, BMI≥30) were voluntarily selected and randomly divided into experimental (n=9) and control (n=9) group. The training group performed 8 weeks of interval training for 8 weeks, 3 sessions each week, 20 minutes every session with 70-75% of target heart rate. Blood samples were collected 24 hours before the first training session and 48 hours after the last training session and after 12 hours of fasting. Data were analyzed by covariance analysis and significant level (P

Tumor necrosis factor alpha (TNF-α) as a pro inflammatory cytokine and interlokin-10 as an anti-inflammatory cytokine have an important role in the development and the prevention of the systemic inflammation and incidence of obesity-induced diseases such as Coronary artery disease respectively .The purpose of this study was determining the effect of eight weeks of swimming training with garlic intake on serum levels of IL-10 and TNF-α in obese male rats.
Subjects and During this experiment 28 Wister male rats with obesity) 250-300 grams (were divided into four groups (control, supplement, training, training supplement) randomly. The training groups swam for 8 weeks, 3 sessions per week and 60 minutes each session. The supplement groups received a solution of garlic extract in dose of 1 milliliter per kilogram of body weight for 8 weeks. Blood samples were taken 48 h after the last training session and the levels of IL-10 and TNF-α were measured. Statistical One-way ANOVA were used for data analysis.
The results showed that eight weeks training and garlic consumption significantly increased the levels of IL-10 and significantly decreased TNF-α in experimental groups (P0.05).
Implementing 8 week of swimming training with garlic intake may have a positive effect on inflammatory factors by increasing IL-10 and decreasing TNF-α.

The use of herbal supplements and exercise training for the treatment of diabetic has increased.The purpose of this study was to investigate the effect of eight weeks high intensity interval training and moderate intensity interval training and Aloe vera intake on serum vaspin and insulin resistance in diabetic male rats.
During this experimental study, 32 diabetic rats with STZ Wistar were randomly divided into four groups including the control, high intensity interval training 닪榕, moderate intensity interval training supplement and supplement. Training program was planned for 8 weeks and 3 sessions per week. Each session consisted of 6 to 12 periods of 2-minute activity with the intensity of 90% and 60% with one minute rest (speed: 10m/min). In the supplement groups, 300milligrams Aloe vera solution per kilogram of body weight Gavage was given 5 sessions per week for 8 weeks. The data were analyzed using one-way analysis of variance (ANOVA).
The results showed that high and moderate intensity interval training with supplement has no significant effect on the of serum vaspin (p=0.112). High intensity interval training with supplement had significant effects on insulin in diabetic male rats (0.000).
.Based on the findings of this study, it seems that supplementation of Aloe vera with high intensity interval training can have better effects on serum insulin in diabetic rats.

Adipose tissue controls the regulation of metabolic responses through semi hormone secretions, specifically adipokines. Fat control can prevent the relevant diseases.This study aimed to examine the effect of interval training with curcumin consumption on some adipokines in menopausal obese rats.
In this experimental study, 28 Wistar menopausal fat rats aged 24months were randomly divided into four groups: control, supplement, training, and training supplement.Training program was planned for 8 weeks and 3 sessions per week. Each session consisted of 10 activity sets in one minute with the intensity of 50% and 2 minutes rest between the sets. In the first week, subjects started with 14 meters per minute and increased their speed to 28 meters per minute till the eighth week. In the supplement groups, 30 milligrams curcumin solution per kilogram of body weight were injected 3 sessions per week for 8 weeks. Blood samples were taken after the last training session and the levels of adiponectin, chemerin, glucose, insulin and insulin resistance index (HOMA-IR) were measured. One-way analysis of variance (ANOVA) and Pearson’s correlation coefficient were used for data analysis.
In the experimental groups, adiponectin concentration increased (P=0.015) and chemerin concentration (P=0.020) and insulin resistance index decreased (P=0.008). There was a significant negative correlation between adiponectin and chemerin in the training group (P=0.030, r=-0.803).
It seems that the interval training with curcumin consumption affects serum adiponectin chemerin and insulin resistance index and in this way can play a major role in reducing the inflammatory responses caused by overweight and obesity.