فهرست مطالب صدیقه گراوند
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IntroductionOlive leaf contains anti-inflammatory and COX-2 inhibitor compounds. Considering the role of the COX enzyme in seizures, this research was performed to assess the effects of this extract in treatment of seizures induced by PTZ.MethodsIn this research, male Wistar rats (200±20 g) were injected intra-cerebroventricularly with 1 μl saline or olive leaf extract (125 μg, 250 μg and 500 μg), before the intraperitoneal administration of PTZ (80 mg/kg) for induction of seizure. Then, seizure score and onset times of every stage of seizure were recorded during 20 minutes after PTZ administration. The data was analyzed by one-way analysis of variance (ANOVA) and non parametric tests.ResultsResult of this research showed that the injection of 125, 250 and 500 μg of olive leaf extract had no effect on the onset time of seizure stages 1, 2 and 3 compared to the control group (P>0.05). However, they significantly decreased the onset time of seizure stages 4 and 5 compared to the control group (P<0.05). On the other hand, olive leaf extract decreased onset time of generalized (tonic-clonic) seizures, but had no effect on partial seizures. Different doses of olive leaf extract had no effect on seizure scores.ConclusionOlive leaf extract has convulsive property and this effect is time and dose dependent.
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IntroductionFlunixin Meglumine (FM) is a nonsteroidal antiinflammatory drug (NSAID) and nonselective cyclooxygenase (COX) inhibitor. Since it has been suggested that COX enzyme plays a role in seizure, this research is performed to assess the therapeutic effects that this compound might have in seizures induced by PTZ.MethodsIn this research, male wistar rats (200 ± 20 g) were given intracerebroventricular injections of saline or FM (12.5 μg, 25 μg and 50 μg) in a 1 μl volume, before intraperitoneal administration of PTZ (80 mg/kg) for induction of seizure. Then, seizure score and times of onset for every stage of seizure were recorded during 20 minutes after PTZ administration. The data were analyzed by one-way analysis of variance (ANOVA).Resultsinjection of 25 and 50 μg of FM significantly increased times of onset of every seizure stage compared to the control group. The group that received 50 μg of FM did not show stage 5. On the other hand, 12.5 μg FM group did not show any significant difference with the control group.ConclusionWe conclude that FM has dose dependent anticonvulsive properties.
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